Here is a brief introduction to this compound(22426-30-8)Recommanded Product: 2-Cyano-2-methylpropanoic acid, if you want to know about other compounds related to this compound(22426-30-8), you can read my other articles.
Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the American Chemical Society called Effect of structure on kinetics and mechanism of the alkaline hydrolysis of anilides, Author is Biechler, Sydney S.; Taft, Robert W. Jr., which mentions a compound: 22426-30-8, SMILESS is CC(C)(C#N)C(O)=O, Molecular C5H7NO2, Recommanded Product: 2-Cyano-2-methylpropanoic acid.
The rates of the aqueous alk. hydrolysis of CF3CONHPh (I) and a series of N-methylanilides, RCONMePh (II), were determined at 2.55° spectrophotometrically. I (3.5 g.) in 60 cc. dry Me2CO treated with 3.7 g. powd. KOH and 1.7 cc. MeI in 10 cc. dry Me2CO, refluxed 0.5 hr., and filtered, the filtrate evaporated, the residual oil diluted with H2O and extracted with Et2O, and the extract worked up gave MePhNCOCF3, m. 25-6°. PhNHMe, 6.4 g. HCO2H, and 20 cc. PhMe refluxed with the azeotropic removal of H2O and distilled gave MePhNCHO, b15 130°, n25D 1.552. PhNH2 (5 g.), a pinch of powd. KOH, and 4 g. CHF2CO2Et refluxed 2 days gave PhNHCOCHF2, m. 58° (aqueous EtOH). PhOCH2COCl (5 g.) in 25 cc. dry Et2O treated dropwise with MeNHPh until the reaction ceased and filtered, and the filtrate washed and worked up gave PhOCH2CONMePh, m. 92-3° (aqueous EtOH). In the same manner was prepared ClCH2CONMePh (III), m. 68-9° (aqueous EtOH). III (7.7 g.) and 10 cc. Me3N heated 3 hrs. in 20 cc. absolute EtOH and the resulting viscous liquid dried over refluxing xylene in a drying pistol gave betaine-N-methylanilide, hygroscopic solid. NCCH2CO2Et (20 g.) added to 10 g. Na in 100 g. absolute EtOH, the mixture treated with cooling with 50 cc. MeI in 20 cc. EtOH, refluxed 4 hrs., and evaporated, the residue diluted with H2O and extracted with Et2O, and the extract worked up gave NCCMe2CO2Et, b15 75°, n25D 1.4098; the ester saponified, the acid, m. 54-5°, converted to the acid chloride, b13 58°, and this dissolved in Et2O and treated dropwise with PhNHMe gave Me2C(CN)CONMePh, m. 55-6° (aqueous EtOH). I (0.328 g.) and 0.679M NaOH in aqueous dioxane kept 2 days and extracted with Et2O, and the extract dried and treated with dry HCl yielded 54.4% PhNH2.HCl; the aqueous layer treated with 10 cc. concentrated HCl and extracted with Et2O, the Et2O removed at 33°, and the residue titrated with NaOH showed 59.6% recovery of CF3CO2H. The rate constants, k1 × 103 min.-1 for the alk. hydrolysis of I in 50% aqueous dioxane at a constant ionic strength (0.500M) and in H2O at 25°, were determined at various concentrations of hydroxyl ion (M concentration of OH- given); the hydrolysis proceeded by 1st-order kinetics, and proceeded by the rate law k1 = k2(OH-)/1 + (OH-)K. The rate constants, k1 min.-1, for the II (R = CF3, CHF2, CH2Cl, CH2N+Me3, CMe2CN, CH2OPh, H) were determined in H2O at 25.5° in the presence and absence of Na2SO4 at varying hydroxyl ion and added salt concentrations The rate law followed by the II is k1 = k2(OH-) + k3(OH-)2. The ratio k3/k2 for the hydrolysis in H2O at 25.5° and an ionic strength of 0.6M was determined for the various II (R and ratio given): CF3 190, CHF2 34, CMe2CN 0.5, CH2OPh 0.7, H 3.4, CH2Cl 2.0, CH2N+Me3 5.6. The mechanism of the hydrolysis of I and II is discussed and correlated with the exptl. data.
Here is a brief introduction to this compound(22426-30-8)Recommanded Product: 2-Cyano-2-methylpropanoic acid, if you want to know about other compounds related to this compound(22426-30-8), you can read my other articles.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method