Safety of 5-Hydroxynicotinic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Hydrothermal synthesis and crystal structure of a 2D zinc(II) coordination polymer with 5-hydroxynicotinic acid. Author is Zhang, Jin; Chen, Hong-Ji; Huang, Jing.
The title compound, [Zn(5-hydroxynicotinate)2·2H2O]n, was synthesized by reacting zinc sulfate vitriol with 5-hydroxynicotinic acid under hydrothermal conditions, and its structure was determined by x-ray crystallog. with the following data: monoclinic, space group C12H12N2O8Zn, Mr = 377.61, a 10.223(3), b 10.319(3), c 13.613(4) Å, β 105.922(6)°, Z = 4, F(000) = 768, dc = 1.816 g/cm3, μ(MoKα) = 1.826 mm-1, the final R = 0.0401 and Rw = 0.1380 for 1157 observed reflections (I > 2σ(I)). In the structure of the title compound, the ZnII ion located in an inversion center lies in a distorted tetrahedral environment at a N2O2 coordination mode, and the 5-hydroxynicotinic acid ligand links symmetry-related ZnII ions at a μ2-N,O bridging way forming a two-dimensional covalent structure. In the crystal, solvent water mols. form intermol. O-H···O hydrogen bonds and pyridine rings of adjacent layers form π-π stacking (3.346 Å), which connect adjacent two-dimensional sheets into a three-dimensional supramol. network.
This compound(5-Hydroxynicotinic acid)Safety of 5-Hydroxynicotinic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method