The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The tautomerism of N-heteroaromatic hydroxy compounds. III. Ionization constants》. Authors are Mason, S. F..The article about the compound:Isoquinolin-6-olcas:7651-82-3,SMILESS:OC1=CC2=C(C=NC=C2)C=C1).Computed Properties of C9H7NO. Through the article, more information about this compound (cas:7651-82-3) is conveyed.
cf. C.A. 52, 4324b. Acidic and basic ionization constants are reported for a number of N-heteroaromatic hydroxy compounds and their O- and N-Me derivatives From the measured and from published values, tautomeric equilibrium constants (Kt = [NH form]/[OH form]) were estimated for the monoaza compounds, and for the diaza compounds with not more than one N atom conjugated with the OH group. For the diazacompds. with a ring-N atom placed both ortho and para to the OH group, the equilibrium constant (Kop = [ο-quinonoid NH form]/[p-quinonoid NH form]) was similarly estimated Such constants agree, to within an order of magnitude, with those determined spectrophotometrically. The ionization and tautomeric constants vary with the π-electron energies of the species in equilibrium Absorption spectra were measured with a Hilger Uvispek H700/305 Quartz Spectrophotometer, and aqueous solutions with pH values 2 units less than pK1 value of the 63 compounds examined Ionization constants were determined by potentiometric titration at 20° under N, a Cambridge pH meter being used with glass and calomel electrodes. The ionization constants of the N-heteroaromatic hydroxy compounds were measured at 0.004M and those of the O- and N-Me derivatives at 0.01M.
This compound(Isoquinolin-6-ol)Computed Properties of C9H7NO was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method