Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about An efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation. Author is Zhang, Dawei; Chen, Xiaodong; Guo, Xue; Zhang, Yumin; Hou, Yaya; Zhao, Tianqi; Gu, Qiang.
An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, Et acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86-96 %), and were characterized by HRMS, FTIR, 1H NMR, and 13C NMR spectroscopy. Solid support SiO2 possesses favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO2. Moreover, the crystal structure of compound di-Et 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented.
This compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method