The Absolute Best Science Experiment for 72287-26-4

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 1246765-38-7!, 72287-26-4

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Enguehard, Cecile and a compound is mentioned, 72287-26-4, [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II), introducing its new discovery. 72287-26-4

(Hetero)arylation of 6-halogenoimidazo[1,2-a]pyridines differently substituted at C(2): Influence of the 2-substituent on the Suzuki cross-coupling reaction

We previously reported that reactivity towards the Suzuki cross-coupling reaction of 3-iodoimidazo[1,2-a]pyridines substituted at C(2) is largely influenced by the nature of this 2-substituent. Hence, with the aim to expand the scope of this coupling process to the 6-position of this series, it seemed important to similarly determine the influence of the nature of the 2-substituent (H, alkyl, or aryl) on the rate of coupling. From this work, the Suzuki-type cross-coupling was shown to proceed efficiently on 6-bromo-2-methyl- and 2-(4-fluorophenyl)imidazo[1,2-a]pyridines, whereas the 6-Br derivative unsubstituted at C(2) appeared to be poorly reactive. By modifying the reaction conditions in terms of catalyst and base, and the nature of the halogen, the reactivity of the unsubstituted series was largely enhanced. Finally, this work led us to establish efficient and convenient Suzuki reaction conditions for the 6-(hetero)arylation of 6-halogenoimidazo[1,2-a]pyridines depending on the nature of the 2-substituent and boronic acid.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 1246765-38-7!, 72287-26-4

Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method