Related Products of 53199-31-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 53199-31-8, Bis(tri-tert-butylphosphine)palladium, introducing its new discovery.
Potent and highly selective benzimidazole inhibitors of PI3-kinase delta
Inhibition of PI3Kdelta is considered to be an attractive mechanism for the treatment of inflammatory diseases and leukocyte malignancies. Using a structure-based design approach, we have identified a series of potent and selective benzimidazole-based inhibitors of PI3Kdelta. These inhibitors do not occupy the selectivity pocket between Trp760 and Met752 that is induced by other families of PI3Kdelta inhibitors. Instead, the selectivity of the compounds for inhibition of PI3Kdelta relative to other PI3K isoforms appears to be due primarily to the strong interactions these inhibitors are able to make with Trp760 in the PI3Kdelta binding pocket. The pharmacokinetic properties and the ability of compound 5 to inhibit the function of B-cells in vivo are described.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 53199-31-8. In my other articles, you can also check out more blogs about 53199-31-8
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method