Reference of 1445085-55-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 1445085-55-1, Methanesulfonato(2-dicyclohexylphosphino-2′,4′,6′-tri-i-propyl-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)palladium(II), introducing its new discovery.
Mild and Functional Group Tolerant Method for Tandem Palladium-Catalyzed Carbocyclization-Coupling of ?-Acetylenic beta-Ketoesters with Aryl Bromides and Chlorides
We report a new protocol for the annulative difunctionalization of acetylenes via tandem carbocyclization-coupling of ?-acetylenic beta-ketoesters with aryl and heteroaryl bromides and chlorides catalyzed by the palladium species derived from an air- and moisture-stable palladacyclic precatalyst. In the tandem process, the palladium complex combines appropriate carbophilic Lewis acidity and redox activity to catalyze two mechanistically distinct reactions – nucleophilic addition of the enolate to unactivated alkyne, followed by C-C coupling. We found that a broad range of electronically varied aryl and heteroaryl bromides and chlorides underwent this reaction with various ?-acetylenic beta-ketoesters, providing corresponding substituted vinylidenecyclopentanes in high yield with excellent functional group tolerance.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 1445085-55-1. In my other articles, you can also check out more blogs about 1445085-55-1
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method