52409-22-0, Name is Pd2(DBA)3, belongs to catalyst-palladium compound, is a common compound. HPLC of Formula: C51H42O3Pd2In an article, once mentioned the new application about 52409-22-0.
Rapid access to diverse alpha-carbolines through sequential transition metal catalyzed amination and direct C-H arylation
An efficient sequence of Pd catalyzed amination and direct C-H arylation for a synthesis of pharmacologically important alpha-carbolines is described. The outstanding feature in the synthetic sequence is that a combination of DBU and 2-(dicyclohexylphosphino)biphenyl (DCHPB) plays a critical role to not only enhance the reactivity but also suppress hydrodehalogenation in the direct C-H arylation step. The reaction protocol provides alpha-carbolines with various substituents including base-sensitive ester and ketone moieties in moderate to excellent yields. Moreover, combination with Cu catalyzed amination further enhanced the versatility of the alpha-carboline synthesis.
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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method