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The research on the area of glycosyl urea derivatives, in which the O- and N-glycosidic bonds are replaced with the urea-glycosidic linkages, has recently emerged with applications in the field of aminoglycoside antibiotics. We have developed a novel method for the stereoselective synthesis of alpha- and beta-glycosyl ureas via Pd(II)-catalyzed rearrangement of glycal trichloroacetimidates. In our approach, the alpha- and beta-selectivity at the anomeric carbon of N-glycosyl trichloroacetamides depends on the nature of the palladium-ligand catalyst. While the cationic Pd(II)-L-4 (2-trifluoroacetylphenol) complex promotes alpha-selectivity, the neutral Pd(II)-TTMPP-L-5 (4-chloro-2-trifluoroacetylphenol) complex favors beta-selectivity. The resulting alpha- and beta-N-glycosyl trichloroacetamides were further coupled with a diverse array of primary and hindered secondary nitrogen nucleophiles to provide the corresponding glycosyl ureas in moderate to good yields and with no loss of stereochemical integrity at the anomeric carbon. We have further demonstrated the utility of N-glycosyl trichloroacetamides as robust and versatile intermediates in the synthesis of unsymmetrical urea-linked disaccharides and trisaccharide.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: Tetrakis(acetonitrile)palladium(II) tetrafluoroborate, you can also check out more blogs about21797-13-7
Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method