One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: catalyst-palladium, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 95464-05-4, Name is 1,1′-Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex, molecular formula is C35H32Cl4FeP2Pd
Novel quinazolinone based alpha-glucosidase inhibitors have been developed. For this purpose a virtual screening model has been generated and validated utilizing acarbose as a alpha-glucosidase inhibitor. Homology modeling, docking, and virtual screening were successfully employed to discover a set of structurally diverse compounds active against alpha-glucosidase. A search of a 3D database containing 22 500 small molecules using the structure based virtual model yielded ten possible candidates. All ten candidates were N-3-pyridyl-2-cyclopropyl quinazolinone-4-one derivatives, varying at the 6 position. This position was modified by Suzuki-Miyaura cross coupling with aryl, heteroaryl, and alkyl boronic acids. A catalyst screen was performed, and using the best optimal conditions, a series of twenty five compounds was synthesized. Notably, the C-C cross coupling reactions of the 6-bromo-2-cyclopropyl-3- (pyridyl-3-ylmethyl)quinazolin-4(3H)-one precursor have been accomplished at room temperature. A comparison of the relative reactivities of 6-bromo and 6-chloro-2,3-disubstituted quinazolinones with phenyl boronic acid was conducted. An investigation of pre-catalyst loading for the reaction of the 6-bromo-2-cyclopropyl-3-(pyridyl-3-ylmethyl)quinazolin-4(3H)-one substrate was also carried out. Finally, we submitted our compounds to biological assays against alpha-glucosidase inhibitors. Of these, three hits (compounds 4a, 4t and 4r) were potentially active as alpha-glucosidase inhibitors and showed activity with IC50 values <20 muM. Based on structural novelty and desirable drug-like properties, 4a was selected for structure-activity relationship study, and thirteen analogs were synthesized. Nine out of thirteen analogs acted as alpha-glucosidase inhibitors with IC50 values <10 muM. These lead compounds have desirable physicochemical properties and are excellent candidates for further optimization. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. category: catalyst-palladium, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 95464-05-4, in my other articles.
Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method