Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7651-82-3, is researched, SMILESS is OC1=CC2=C(C=NC=C2)C=C1, Molecular C9H7NOJournal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called RadH: A Versatile Halogenase for Integration into Synthetic Pathways, Author is Menon, Binuraj R. K.; Brandenburger, Eileen; Sharif, Humera H.; Klemstein, Ulrike; Shepherd, Sarah A.; Greaney, Michael F.; Micklefield, Jason, the main research direction is RadH halogenase halogenation; biocatalysis; directed evolution; enzyme mechanisms; halogenases; pathway engineering.Product Details of 7651-82-3.
Flavin-dependent halogenases are useful enzymes for providing halogenated mols. with improved biol. activity, or intermediates for synthetic derivatization. We demonstrate how the fungal halogenase RadH can be used to regioselectively halogenate a range of bioactive aromatic scaffolds. Site-directed mutagenesis of RadH was used to identify catalytic residues and provide insight into the mechanism of fungal halogenases. A high-throughput fluorescence screen was also developed, which enabled a RadH mutant to be evolved with improved properties. Finally we demonstrate how biosynthetic genes from fungi, bacteria, and plants can be combined to encode a new pathway to generate a novel chlorinated coumarin “”non-natural”” product in E. coli.
There is still a lot of research devoted to this compound(SMILES：OC1=CC2=C(C=NC=C2)C=C1)Product Details of 7651-82-3, and with the development of science, more effects of this compound(7651-82-3) can be discovered.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method