Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7651-82-3, is researched, SMILESS is OC1=CC2=C(C=NC=C2)C=C1, Molecular C9H7NOJournal, Article, Research Support, Non-U.S. Gov’t, Nature Chemistry called Time-dependent enantiodivergent synthesis via sequential kinetic resolution, Author is Tu, Hang-Fei; Yang, Pusu; Lin, Zi-Hua; Zheng, Chao; You, Shu-Li, the main research direction is hydroxyisoquinoline allylic carbonate iridium enantioselective allylic substitution kinetic resolution; chiral amine preparation.Category: catalyst-palladium.
The preparation of both enantiomers of chiral mols. is among the most fundamental tasks in organic synthesis, medicinal chem. and materials science. Achieving this goal typically requires reversing the absolute configuration of the chiral component employed in the reaction system that is being used. The task becomes challenging when the natural source of the chiral component is not available in both configurations. Herein, we report a time-dependent enantiodivergent synthesis, in which an Ir-catalyzed allylic substitution reaction uses one catalyst sequentially to promote two kinetic resolution reactions, enabling the synthesis of both enantiomers of the product using the same enantiomer of a chiral catalyst. The appropriate permutation of individual reaction rates is essential for the isolation of the chiral products in opposite configurations with high enantiopurity when quenched at different reaction times. This work provides an alternative solution for the preparation of both enantiomers of chiral mols.
If you want to learn more about this compound(Isoquinolin-6-ol)Category: catalyst-palladium, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(7651-82-3).
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method