The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol(SMILESS: OCC1=CC(C2=CC=CC=C2Cl)=NO1,cas:438565-33-4) is researched.SDS of cas: 18436-73-2. The article 《Synthesis of isoxazolines and isoxazoles using poly(ethylene glycol) as support》 in relation to this compound, is published in Synthesis. Let’s take a look at the latest research on this compound (cas:438565-33-4).
A general method for the liquid-phase syntheses of isoxazoles and isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkyne or alkene reacted with nitrile oxides generated in situ from aldoximes, followed by cleavage from the PEG, to give isoxazoles or isoxazolines in good yield and purity.
This literature about this compound(438565-33-4)Formula: C10H8ClNO2has given us a lot of inspiration, and I hope that the research on this compound(3-(2-Chlorophenyl)-5-isoxazolemethanol) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method