Recommanded Product: Chloro(1,5-cyclooctadiene)(pentamethylcyclopentadienyl)ruthenium. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Chloro(1,5-cyclooctadiene)(pentamethylcyclopentadienyl)ruthenium, is researched, Molecular C18H28ClRu, CAS is 92390-26-6, about Protein Prosthesis: 1,5-Disubstituted[1,2,3]triazoles as cis-Peptide Bond Surrogates. Author is Tam, Annie; Arnold, Ulrich; Soellner, Matthew B.; Raines, Ronald T..
Here, 1,5-disubstituted[1,2,3]triazoles were assessed as cis-peptide bond surrogates. Ruthenium-catalyzed Huisgen’s 1,3-dipolar cycloaddition reaction of amino alkynes and azido acids was used to synthesize a variety of Xaa-1,5-triazole-Ala modules (Xaa = Asn, Ala) in moderate-to-high yields. Two of these modules, along with their 1,4-triazole regioisomers, were installed in a turn region of bovine pancreatic RNase (RNase A; 124 residues) by using expressed protein ligation. The resulting semisynthetic enzymes displayed full enzymic activity, indicating the maintenance of native structure. The 1,5-triazole surrogates instilled conformational stability that was comparable to that of Xaa-cis-Pro segments, whereas the 1,4-triazoles conferred markedly less stability. The stability conferred by both surrogates was independent of the Xaa residue, eliminating an uncertainty in protein design. The authors conclude that Xaa-1,5-triazole-Ala modules can serve as viable mimics of Xaa-cis-Pro segments. The possibility of synthesizing this surrogate by the ligation of fragments in situ and the emergence of biocompatible catalysts for that process portends its widespread use.
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Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method