Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: PD2DBA3, is researched, Molecular C51H42O3Pd2, CAS is 60748-47-2, about Convenient, Large-Scale Synthesis of (S)-TRIP Using Suzuki Cross-Coupling Conditions.Application of 60748-47-2.
A three-step synthesis of (S)-TRIP enabled by efficient Suzuki cross-coupling conditions using com. starting materials was developed and demonstrated on a kilogram scale. These novel Suzuki reaction conditions feature Pd2(dba)3/CataCXium A in the presence of TBAB and KOH and provide conversions up to 90% while minimizing the formation of common byproducts. Following an improved demethylation protocol and a powerful MeOH purification protocol during step 2, high-quality catalyst of up to 99% purity was isolated in 52% yield over three steps.
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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method