New downstream synthetic route of 22426-30-8

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Cyano-2-methylpropanoic acid, is researched, Molecular C5H7NO2, CAS is 22426-30-8, about Discovery of N-benzyl-N’-(4-piperidinyl)urea CCR5 antagonists as anti-HIV-1 agents (II): Modification of the acyl portion, the main research direction is benzyl piperidine urea preparation antiHIV1 SAR.Recommanded Product: 22426-30-8.

Modification of the acyl moiety in the CCR5 lead mol. 2 led to identification of several new classes of CCR5 antagonists. Antiviral activity and pharmacokinetic properties of the synthesized compounds were evaluated. Structure-activity relationship (SAR) derived from these studies further guided the optimization efforts, ultimately leading to the discovery of 36 (I) with an acceptable drug-like profile.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method