Wang, Xi-Zhao; Jia, Jiong; Zhang, Yan; Xu, Wei-Ren; Liu, Wei; Shi, Fang-Niu; Wang, Jian-Wu published the article 《Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins》. Keywords: isoxazole penicillin derivative preparation antibacterial amidation dipolar cycloaddition.They researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:438565-33-4) here.
The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C6H4-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO2, -4-NO2, -3-CF3, -4-CF3, C6H3-2,4-Cl2, -3,4-Cl2, C6H2-2,4,5-Cl3, -3,4,5-Cl3, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH2OH using CuSO4.5H2O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.
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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method