In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 52409-22-0, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52409-22-0, name is Pd2(DBA)3. In an article，Which mentioned a new discovery about 52409-22-0
Synthesis and Structure-Activity Relationships of 1-Aryl-beta-carbolines as Affinity Probes for the 5-Hydroxytryptamine Receptor
Simple beta-carbolines have been shown to bind several protein receptors that are important for signaling in the central nervous system. Herein, we expand our previous efforts into the synthesis and biological activity of these heterocycles by studying their neuropharmacological activity. A diverse set of 1-aryl-beta-carbolines has been synthesized via Suzuki cross-coupling from a common triflate precursor and several substituted aryl boronic acids. The resulting 26-member library was subjected to primary screening at 10 muM for activity against 40 protein receptors implicated in brain signaling. The Ki was subsequently determined for several lead structures. The most potent activity, as low as 100 nM, was found against the 5-hydroxytryptamine subtype-2 family of receptors. In-depth structure-activity relationships for these synthetic beta-carbolines have been developed, which point to the importance of a 3-indolyl substituent attached to the 1-position of the beta-carboline and a 6-methoxy substituent on the beta-carboline core.
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Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method