A new synthetic route of 7651-82-3

From this literature《Biaryl substituted hydantoin compounds as TACE inhibitors》,we know some information about this compound(7651-82-3)Recommanded Product: 7651-82-3, but this is not all information, there are many literatures related to this compound(7651-82-3).

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7651-82-3, is researched, SMILESS is OC1=CC2=C(C=NC=C2)C=C1, Molecular C9H7NOJournal, Article, Bioorganic & Medicinal Chemistry Letters called Biaryl substituted hydantoin compounds as TACE inhibitors, Author is Yu, Wensheng; Tong, Ling; Kim, Seong Heon; Wong, Michael K. C.; Chen, Lei; Yang, De-Yi; Shankar, Bandarpalle B.; Lavey, Brian J.; Zhou, Guowei; Kosinski, Aneta; Rizvi, Razia; Li, Dansu; Feltz, Robert J.; Piwinski, John J.; Rosner, Kristin E.; Shih, Neng-Yang; Siddiqui, M. Arshad; Guo, Zhuyan; Orth, Peter; Shah, Himanshu; Sun, Jing; Umland, Shelby; Lundell, Daniel J.; Niu, Xiaoda; Kozlowski, Joseph A., the main research direction is biaryl hydantoin preparation TACE inhibitor SAR.Recommanded Product: 7651-82-3.

We disclose further optimization of hydantoin TNF-α convertase enzyme (TACE) inhibitors. SAR with respect to the non-prime region of TACE active site was explored. A series of biaryl substituted hydantoin compounds was shown to have sub-nanomolar K i, good rat PK, and good selectivity vs. MMP-1, -2, -3, -7, -9, and -13.

From this literature《Biaryl substituted hydantoin compounds as TACE inhibitors》,we know some information about this compound(7651-82-3)Recommanded Product: 7651-82-3, but this is not all information, there are many literatures related to this compound(7651-82-3).

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method