The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Isoquinolin-6-ol(SMILESS: OC1=CC2=C(C=NC=C2)C=C1,cas:7651-82-3) is researched.Computed Properties of C18H28ClRu. The article 《Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation》 in relation to this compound, is published in Nature Communications. Let’s take a look at the latest research on this compound (cas:7651-82-3).
The integration of regioselective halogenase enzymes with Pd-catalyzed cross-coupling chem., in one-pot reactions, successfully addresses this problem for the indole heterocycle was demonstrated. The resultant ‘chemobio-transformation’ delivered a range of functionally diverse arylated products that were impossible to access using sep. enzymic or chemocatalytic C-H activation, under mild, aqueous conditions. This use of different biocatalysts to select different C-H positions contrasts with the prevailing substrate-control approach to the area, and presented opportunities for new pathways in C-H activation chem. The issues of enzyme and transition metal compatibility were overcome through membrane compartmentalization, with the optimized process requiring no intermediate work-up or purification steps.
The article 《Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation》 also mentions many details about this compound(7651-82-3)Reference of Isoquinolin-6-ol, you can pay attention to it, because details determine success or failure
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method