130-95-0, Quinine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
QN (quinine) 3.24 g (10 mmol) and sodium hydride 0.80 g (200 mmol, respectively) were weighed.2 times equivalent) was added to a three-neck reaction flask. In addition, the air is replaced by argon gas.After replacement, 30 mL of anhydrous tetrahydrofuran (anhydrous) was added under ice bath and argon protection.DMF), after stirring for 1 hour, slowly add dropwise.Add 1.5 mL of benzyl chloride (13 mmol; 1.3 equivalents) and stir while stirring.After the addition is complete, remove the ice bath. After reacting at room temperature for 6 hours, after the reaction is completed,Quenched with saturated ammonium chloride, extracted with ethyl acetate and extracted three times.The upper organic layer was collected, washed twice with water, and once with saturated brine.Dry over anhydrous sodium sulfate, filter, concentrate,Drying gave 3.93 g of a milky white solid 2a in a yield of 95%.
130-95-0, 130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Patent; Xinxiang Medical University; Wang Yakun; Zhang Tao; Zhang Jixia; Liu Yufei; Li Guowei; Li Nan; (14 pag.)CN108947998; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI