Electric Literature of 53199-31-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 53199-31-8, Name is Bis(tri-tert-butylphosphine)palladium, molecular formula is C24H54P2Pd. In a Article£¬once mentioned of 53199-31-8
Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures
With the aim of identifying new lead structures for EGFR inhibition, a study of palladium catalysed Heck coupling between (R)-6-bromo-N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine and various acrylates was performed. The Heck coupling was highly dependent on type of catalyst, solvent, base type and the use of tetrabutylammonium chloride as additive. The products were stable in the dark, but underwent trans-cis isomerization upon exposure to light. Kinase profiling indicate that acrylates grafted on the [2,3-d]thienopyrimidines is an attractive scaffold for identification of potent and highly selective EGFR inhibitors.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 53199-31-8. In my other articles, you can also check out more blogs about 53199-31-8
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method