Related Products of 52409-22-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 52409-22-0, Pd2(DBA)3, introducing its new discovery.
Regio-, Diastereo- and Enantioselective Synthesis of Piperidines with Three Stereogenic Centers from Isoxazolinones by Palladium/Iridium Relay Catalysis
Piperidines are currently the most frequently used heterocycles in the development of new pharmaceuticals. A straightforward efficient stereo- and regioselective asymmetric access to chiral polysubstituted piperidines creating multiple stereogenic centers is often still a challenge. Herein we report a rapid approach towards trisubstituted piperidines, which is notable for the use of a readily accessible isoxazolinone starting material and for creating three stereocenters in a single step. 3,4-Dihydropyridines, which are probably formed by a Pd-catalyzed cycle via a decarboxylative oxidative addition of the substrates, appear to be useful intermediates in this relay catalysis, in which Ir acts as enantioselective hydrogenation catalyst to form the valuable chiral heterocycles under mild conditions.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 52409-22-0. In my other articles, you can also check out more blogs about 52409-22-0
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method