Synthetic Route of C10H8ClNO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Synthesis of isoxazole moiety containing ferrocene derivatives and preliminarily in vitro anticancer activity. Author is Yong, Jianping; Lu, Canzhong; Wu, Xiaoyuan.
Seven isoxazole-ring-containing ferrocene derivatives were synthesized and characterized by 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116, and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, ferrocenecarboxylic acid 3-(2-chlorophenyl)isoxazol-5-ylmethyl ester (3d) exhibited wide spectrum anticancer activity and is the most potent among the isoxazole-ring-containing ferrocene derivatives Compound 3d is more active against A549 and HCT116 cell lines (IC50s: 0.747 and 3.65 nM, resp.) than the reference drug gefitinib (IC50s: 17.90 and 21.55 μM, resp.). 3D can be seen as the best candidate for development of anticancer drugs.
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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method