Awesome and Easy Science Experiments about 7651-82-3

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Isoquinolin-6-ol( cas:7651-82-3 ) is researched.Related Products of 7651-82-3.Zhang, Yujiao; Xie, Kebo; Liu, Aijing; Chen, Ridao; Chen, Dawei; Yang, Lin; Dai, Jungui published the article 《Enzymatic biosynthesis of benzylisoquinoline alkaloid glycosides via promiscuous glycosyltransferases from Carthamus tinctorius》 about this compound( cas:7651-82-3 ) in Chinese Chemical Letters. Keywords: Carthamus glycosyltransferase benzylisoquinoline alkaloid. Let’s learn more about this compound (cas:7651-82-3).

Enzymic glycosylation catalyzed by glycosyltransferases (GTs) has great potential in creating diverse novel and bioactive glycosides. Herein, three new GTs (UGT84A33, UGT71AE1 and UGT90A14) from Carthamus tinctorius exhibited robust catalytic promiscuity to benzylisoquinoline alkaloids, and were used as enzymic tools in glycosylation of bioactive benzylisoquinoline alkaloids. Seven novel benzylisoquinoline alkaloids O-glycosides were synthesized with high efficiency. These studies indicate the significant potential of promiscuous GTs in synthesis of benzylisoquinoline alkaloids glycosides for drug discovery.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method