The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Cyano-2-methylpropanoic acid( cas:22426-30-8 ) is researched.Reference of 2-Cyano-2-methylpropanoic acid.Eberson, Lennart; Nilsson, Sven published the article 《Kolbe electrolytic synthesis. VIII. Electrolysis of α-cyanocarboxylates》 about this compound( cas:22426-30-8 ) in Acta Chemica Scandinavica (1947-1973). Keywords: kolbe electrolysis; electrolysis Kolbe; cyanocarboxylate electrolysis; carboxylate electrolysis. Let’s learn more about this compound (cas:22426-30-8).
Isopropyl-, tert-butyl-, cyclohexyl-, and dimethylcyanoacetic acid were electrolyzed in methanolic solution and the radical coupling products determined quant. tert-Butylcyanoacetic acid was also electrolyzed in water, acetonitrile, and N,N-dimethylformamide. From this acid a very low yield of a rearrangement product, 2-cyano-3-methyl-2-butene, was obtained on electrolysis in methanol at a Pt anode; the same low yield was observed when a carbon anode was used. The behavior of anodically generated α-cyanoalkyl radicals is very similar to that of α-cyanoalkyl radicals generated in homogeneous solution, both with regard to the stereochemistry of the reaction and to the proportion between C-to-C and C-to-N-coupling products.
This compound(2-Cyano-2-methylpropanoic acid)Reference of 2-Cyano-2-methylpropanoic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method