153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a three-necked flask equipped with a mechanical stirrer,Add anhydrous methanol 600 mL,D-tryptophan (102.1 g, 500 mmol), Room temperature stirring, using ice salt bath,The temperature of the reaction system was reduced to 0 C,A solution of thionyl chloride (71.4 g, 600 mmol)After the dropwise addition, the temperature was raised to room temperature for about 12 hours.Thin layer chromatography monitoring, when the raw material reaction is complete,Stop the reaction.After atmospheric distillation of most of the remaining thionyl chloride and methanol,Decompression in addition to thionyl chloride and methanol, cooling,To give the hydrochloride of solid tryptophan methyl ester (Isolated from air) can be used directly in the next step., 153-94-6
The synthetic route of 153-94-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Xi hua University; Yang, Weiqing; Li, Hongyang; Wang, Huizhen; (18 pag.)CN106432237; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI