The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: PD2DBA3( cas:60748-47-2 ) is researched.Related Products of 60748-47-2.Holst, Hannah M.; Floreancig, Jack T.; Ritts, Casey B.; Race, Nicholas J. published the article 《Aziridine Opening via a Phenonium Ion Enables Synthesis of Complex Phenethylamine Derivatives》 about this compound( cas:60748-47-2 ) in Organic Letters. Keywords: phenethylamine diastereoselective preparation; unsym disubstituted aziridine preparation titanium tetrachloride ring opening. Let’s learn more about this compound (cas:60748-47-2).
The treatment of unsym. 2,3-disubstituted aziridines with TiCl4 yielded β-phenethylamines I [R1 = H, 4-Me, 4-OMe; R2 = n-Pr, i-Pr, CH2CH(CH3)2, etc.] via the intermediacy of a phenonium ion. Derivatization of the products obtained via this method was demonstrated. Computational anal. of the reaction pathway provided insight into the reaction mechanism, including the selectivity of the phenonium opening.
《Aziridine Opening via a Phenonium Ion Enables Synthesis of Complex Phenethylamine Derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(PD2DBA3)Related Products of 60748-47-2.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method