Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: 1,1′-Bis(di-tert-butylphosphino)ferrocene-palladium dichloride. Introducing a new discovery about 95408-45-0, Name is 1,1′-Bis(di-tert-butylphosphino)ferrocene-palladium dichloride
The mitogen-activated protein kinase p38alpha pathway has been an attractive target for the treatment of inflammatory conditions such as rheumatoid arthritis. While a number of p38alpha inhibitors have been taken to the clinic, they have been limited by their efficacy and toxicological profile. A lead identification program was initiated to selectively target prevention of activation (PoA) of mitogen-activated protein kinase-activated protein kinase 2 (MK2) rather than mitogen- and stress-activated protein kinase 1 (MSK1), both immediate downstream substrates of p38alpha, to improve the efficacy/safety profile over direct p38alpha inhibition. Starting with a series of pyrazole amide PoA MK2 inhibitor leads, and guided by structural chemistry and rational design, a highly selective imidazole 9 (2-(3?-(2-amino-2-oxoethyl)-[1,1?-biphenyl]-3-yl)-N-(5-(N,N-dimethylsulfamoyl)-2-methylphenyl)-1-propyl-1H-imidazole-5-carboxamide) and the orally bioavailable imidazole 18 (3-methyl-N-(2-methyl-5-sulfamoylphenyl)-2-(o-tolyl)imidazole-4-carboxamide) were discovered. The PoA concept was further evaluated by protein immunoblotting, which showed that the optimized PoA MK2 compounds, despite their biochemical selectivity against MSK1 phosphorylation, behaved similarly to p38 inhibitors in cellular signaling. This study highlights the importance of selective tool compounds in untangling complex signaling pathways, and although 9 and 18 were not differentiated from p38alpha inhibitors in a cellular context, they are still useful tools for further research directed to understand the role of MK2 in the p38alpha signaling pathway.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: 1,1′-Bis(di-tert-butylphosphino)ferrocene-palladium dichloride, you can also check out more blogs about95408-45-0
Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method