Category: 27828-71-3

HPLC of Formula: 27828-71-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Poly[[diaquabis(μ-oxalato-κ4O1,O2:O1′,O2′)bis(μ3-5-oxidopyridin-1-ium-3-carboxylato-κ3O3:O3′:O5)diholmium(III)] dihydrate]. Author is Mi, Jun-Long; Huang, Jing; Chen, Hong-Ji.

The crystal structure of Poly[[diaquabis(μ-oxalato-κ4O1,O2:O1′,O2′)bis(μ3-5-oxidopyridin-1-ium-3-carboxylato-κ3O3:O3′:O5)diholmium(III)] dihydrate] has been determined The HoIII atom was coordinated by three O atoms from three 5-hydroxynicotinate ligands, four O atoms from two oxalate ligands, each lying on an inversion center, and one water mol. in a distorted square-antiprismatic geometry. The 5-hydroxynicotinate ligand was protonated at the N atom and deprotonated at the hydroxy group. The HoIII atoms were bridged by the carboxylate and phenolate O atoms, forming a three-dimensional framework. N-H···O and O-H···O hydrogen bonds, as well as π-π interactions between the pyridine rings [centroid-centroid distance = 3.794(2) Å], were observed

This compound(5-Hydroxynicotinic acid)HPLC of Formula: 27828-71-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors, the main research direction is benzoylpiperidine preparation reversible monoacylglycerol lipase inhibitor human antitumor; Benzoylpiperidine derivatives; MAGL; Monoacylglycerol lipase inhibitors.Safety of 5-Hydroxynicotinic acid.

An interesting enzyme of the endocannabinoid system is monoacylglycerol lipase (MAGL). This enzyme, which metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG), has attracted great interest due to its involvement in several physiol. and pathol. processes, such as cancer progression. Exptl. evidences highlighted some drawbacks associated with the use of irreversible MAGL inhibitors in vivo, therefore the research field concerning reversible inhibitors is rapidly growing. In the present manuscript, the class of benzoylpiperidine-based MAGL inhibitors was further expanded and optimized. Enzymic assays identified some compounds in the low nanomolar range and steered mol. dynamics simulations predicted the dissociation itinerary of one of the best compounds from the enzyme, confirming the observed structure-activity relationship. Biol. evaluation, including assays in intact U937 cells and competitive activity-based protein profiling experiments in mouse brain membranes, confirmed the selectivity of the selected compounds for MAGL vs. other components of the endocannabinoid system. Future studies on the potential use of these compounds in the clin. setting are also supported by the inhibition of cell growth observed both in cancer organoids derived from high grade serous ovarian cancer patients and in pancreatic ductal adenocarcinoma primary cells, which showed genetic and histol. features very similar to the primary tumors.

《Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Hydroxynicotinic acid)Safety of 5-Hydroxynicotinic acid.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Safety of 5-Hydroxynicotinic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Hydrothermal synthesis and crystal structure of a 2D zinc(II) coordination polymer with 5-hydroxynicotinic acid. Author is Zhang, Jin; Chen, Hong-Ji; Huang, Jing.

The title compound, [Zn(5-hydroxynicotinate)2·2H2O]n, was synthesized by reacting zinc sulfate vitriol with 5-hydroxynicotinic acid under hydrothermal conditions, and its structure was determined by x-ray crystallog. with the following data: monoclinic, space group C12H12N2O8Zn, Mr = 377.61, a 10.223(3), b 10.319(3), c 13.613(4) Å, β 105.922(6)°, Z = 4, F(000) = 768, dc = 1.816 g/cm3, μ(MoKα) = 1.826 mm-1, the final R = 0.0401 and Rw = 0.1380 for 1157 observed reflections (I > 2σ(I)). In the structure of the title compound, the ZnII ion located in an inversion center lies in a distorted tetrahedral environment at a N2O2 coordination mode, and the 5-hydroxynicotinic acid ligand links symmetry-related ZnII ions at a μ2-N,O bridging way forming a two-dimensional covalent structure. In the crystal, solvent water mols. form intermol. O-H···O hydrogen bonds and pyridine rings of adjacent layers form π-π stacking (3.346 Å), which connect adjacent two-dimensional sheets into a three-dimensional supramol. network.

This compound(5-Hydroxynicotinic acid)Safety of 5-Hydroxynicotinic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Application of 27828-71-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Chemical constituents in n-butanol extracts of Cheanomeles speciosa (Sweet) Nakai. Author is Li, Xia; Yang, Ying-bo; Xi, Zhong-xin; Sun, Lei; Chen, Wan-sheng; Sun, Lian-na.

Chem. constituents in n-butanol extracts of Chaenomeles speciosa were investigated. Multi-chromatog. methods including Silicagel column chromatog. and Sephadex LH-20 gel permeation were employed for the isolation and purification The structures were identified on the basis of chem. evidence and spectral data. Eight compounds were isolated and identified as 1,2,4-Benzenetriol (1), gallic acid (2), epi-quinide (3), 5-Hydroxynicotinic acid (4), p-coumaric acids glucosyl esters (5), p-hydroxybenzoic acid glucoside (6), (6S,9R)-roseoside (7) and Vomifolioll-O-β-D-xylopyranosy-6-O-β-D-glucopyranoside (8). Compounds 1-6 were obtained from this genus for the first time.

This compound(5-Hydroxynicotinic acid)Application of 27828-71-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Use of 8-Substituted-FAD Analogues To Investigate the Hydroxylation Mechanism of the Flavoprotein 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase, published in 2004-04-06, which mentions a compound: 27828-71-3, Name is 5-Hydroxynicotinic acid, Molecular C6H5NO3, Name: 5-Hydroxynicotinic acid.

2-Methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase (MHPCO) is a flavoprotein that catalyzes the oxygenation of MHPC to form α-(N-acetylaminomethylene)-succinic acid. Although formally similar to the oxygenation reactions catalyzed by phenol hydroxylases, MHPCO catalyzes the oxygenation of a pyridyl derivative rather than a simple phenol. Therefore, in this study, the mechanism of the reaction was investigated by replacing the natural cofactor FAD with FAD analogs having various substituents (-Cl, -CN, -NH2, -OCH3) at the C8-position of the isoalloxazine. Thermodn. and catalytic properties of the reconstituted enzyme were investigated and found to be similar to those of the native enzyme, validating that these FAD analogs are reasonable to be used as mechanistic probes. Dissociation constants for the binding of MHPC or the substrate analog 5-hydroxynicotinate (5HN) to the reconstituted enzymes indicate that the reconstituted enzymes bind well with ligands. Redox potential values of the reconstituted enzymes were measured and found to be more pos. than the values of free FAD analogs, which correlated well with the electronic effects of the 8-substituents. Studies of the reductive half-reaction of MHPCO have shown that the rates of flavin reduction by NADH could be described as a parabolic relationship with the redox potential values of the reconstituted enzymes, which is consistent with the Marcus electron transfer theory. Studies of the oxidative half-reaction of MHPCO revealed that the rate of hydroxylation depended upon the different analogs employed. The rate constants for the hydroxylation step correlated with the calculated pKa values of the 8-substituted C(4a)-hydroxyflavin intermediates, which are the leaving groups in the oxygen transfer step. It was observed that the rates of hydroxylation were greater when the pKa values of C(4a)-hydroxyflavins were lower. Although these results are not as dramatic as those from analogous studies with p-hydroxybenzoate hydroxylase, they are consistent with the model that the oxygenation reaction of MHPCO occurs via an electrophilic aromatic substitution mechanism analogous to the mechanisms for p-hydroxybenzoate and phenol hydroxylases.

This compound(5-Hydroxynicotinic acid)Name: 5-Hydroxynicotinic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A highly efficient solution and solid state ESIPT fluorophore and its OLED application, published in 2021, which mentions a compound: 27828-71-3, Name is 5-Hydroxynicotinic acid, Molecular C6H5NO3, Recommanded Product: 27828-71-3.

We present herein the synthesis and photophysics of 2,2′-bipyridine-3,3′-diol-5,5′-dicarboxylic acid Et ester (BP(OH)2DCEt2), an excited state intramol. proton transfer (ESIPT)-based fluorophore featuring two identical intramol. hydrogen bonds. BP(OH)2DCEt2 emits efficiently not only in solution, including protic solvents (λem = 521 nm, Φf = 40 to 75%), but also in crystalline state (λem = 530 nm, Φf = 51%). In addition, its saponified form (Na2BP(OH)2DC) is highly fluorescent in water (λem = 490 nm, Φf = 51%). Finally, the good electroluminescence performance of BP(OH)2DCEt2 is also demonstrated in an OLED device.

This compound(5-Hydroxynicotinic acid)Recommanded Product: 27828-71-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Self-assembly syntheses and crystal structures of triorganotin(IV) pyridinecarboxylate: 1D polymers and a 42-membered macrocycle.SDS of cas: 27828-71-3.

A series of new triorganotin(IV) pyridinecarboxylates with 6-hydroxynicotinic acid (6-OH-3-nicH), 5-hydroxynicotinic acid (5-OH-3-nicH) and 2-hydroxyisonicotinic acid (2-OH-4-isonicH) of the types: [R3Sn (6-OH-3-nic)·L]n (I) (R = Ph, L = Ph·EtOH, 1; R = Bn, L = H2O·EtOH, 2; R = Me, L = 0, 3; R = n-Bu, L = 0, 4), [R3Sn (5-OH-3-nic)]n (II) (R = Ph, 5; R = Bn, 6; R = Me, 7; R = n-Bu, 8), [R3Sn (2-OH-4-isonic·L)]n (III) (R = Bn, 9, L = MeOH; R = Me, L = 0, 10; R = Ph, 11, L = 0.5EtOH) have been synthesized. All the complexes were characterized by elemental anal., TGA, IR and NMR (1H, 13C, 119Sn) spectroscopy analyses. Among them, except for complexes 5 and 6, all complexes were also characterized by x-ray crystallog. diffraction anal. Crystal structures show that complexes 1-10 adopt 1D infinite chain structures which are generated by the bidentate O, O or N, O and the five-coordinated tin centers. Significant O-H···O, and N-H···O intermol. hydrogen bonds stabilize these structures. Complex 11 is a 42-membered macrocycle containing six tin atoms, and forms a 2D network by intermol. N-H···O hydrogen.

《Self-assembly syntheses and crystal structures of triorganotin(IV) pyridinecarboxylate: 1D polymers and a 42-membered macrocycle》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Hydroxynicotinic acid)SDS of cas: 27828-71-3.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Reference of 5-Hydroxynicotinic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Analysis of malondialdehyde and superoxide dismustase levels after exposure of electric cigarette in rats. Author is Lisdiana; Nugrahaningsih, W. H.; Nufus, I..

Elec. cigarette (e-cigarette) is cigarette that operate on battery power to burn liquids and to produce a steam. One of the contents of an elec. cigarette is nicotine. It is a chem. compound that can cause addiction and trigger oxidative stress. This study aims to analyze the levels of malondialdehyde and superoxide dismutase in the blood of rats that exposed to nicotine from e-cigarettes. The study was conducted on 30 male Wistar rats which divided into 5 groups, control group there are neg. and pos. and treatment group with nicotine 0,25 mg, 0,5 mg, 0,75mg with exposure to cigarette smoke for 30 days. Malondialdehyde and superoxide dismutase levels measurements using the TBARs method, the results that can be known using a spectrophotometer with a wavelength of 532 nm. SOD levels were measured by the calorimetry method. The One Way Anova anal. showed that malondialdehyde and superoxide dismutase levels in the control group were significantly different from all groups. The conclusion is that nicotine has an effect on increasing malondialdehyde and decreasing superoxide dismutase levels.

Different reactions of this compound(5-Hydroxynicotinic acid)Reference of 5-Hydroxynicotinic acid require different conditions, so the reaction conditions are very important.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Formula: C6H5NO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Two- and three-dimensional lanthanide metal-organic frameworks with hydroxyl-functionalized nicotinic acid and oxalate ligands. Author is Zhang, Jin; Huang, Jing; Yang, Jun; Chen, Hong-Ji.

LMOFs, consisting of three groups of isostructural compounds, [Ln(3-H-5-phenoxonicotinato)(ox)(H2O)2]n 1 (Ln = La(1a), Pr(1b), Nd(1c), 5-Hydroxynicotinic acid = C6H5NO3, ox = C2O42-), {[Ln(3-H-5-hydroxynicotinato)(ox)1.5(H2O)]·H2O}n 2 [Ln = Sm(2a), Gd(2b), Tb(2c)], and {[Ln(3-H-5-phenoxonicotinato)(ox)(H2O)]·H2O}n 3 (Ln = Dy(3a), Er(3b)), were hydrothermally synthesized and structurally determined by x-ray diffraction analyses. Compounds in Group 1 are constructed by mixed μ3-3-H-5-phenoxonicotinato and oxalate bridging ligands and Ln3+ ions, exhibiting a 3-dimensional covalent network with empty 1-dimensional microchannels, featuring a 3,5-connected topol. Compounds in Group 2 present a brick-well-liked 2-dimensional network generated by both metal ions and oxalate groups at a side-by-side way. Compounds in Group 3 are isotopol. to those in Group 1, accompanying 1-dimensional microchannels being occupied by coordinated H2O mols. Antiferromagnetic interactions between Pr metal centers are observed from the magnetic susceptibility of compound 1b. Luminescence measurements indicate that the Tb complex 2c is a strong green luminescence emitter.

Different reactions of this compound(5-Hydroxynicotinic acid)Formula: C6H5NO3 require different conditions, so the reaction conditions are very important.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Computed Properties of C6H5NO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Probing the mechanism of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase by using 8-substituted-FAD analogs. Author is Sucharitakul, Jeerus; Chaiyen, Pimchai; Ballou, David P.; Massey, Vincent.

The reaction mechanism of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO) was investigated by using FAD-analogs substituted at the 8-position of the isoalloxazine ring. Replacing FAD of MHPCO with different FAD analogs having substituents at the 8-position did not greatly change the enzymic properties when compared with the native enzyme. Binding of the apoenzyme of MHPCO to the FAD analogs resulted in perturbation of the flavin absorbance and the fluorescence. The redox potential values of FAD analogs were shifted to more pos. values when bound to MHPCO. Using stopped-flow spectrophotometry, the oxidized enzyme was mixed with various concentrations of NADH, and the reaction was monitored at different wavelengths. The results indicate that the reaction of MHPCO reconstituted with FAD analogs proceeds through hydroxylation mechanisms similar to those for native enzyme.

Different reactions of this compound(5-Hydroxynicotinic acid)Computed Properties of C6H5NO3 require different conditions, so the reaction conditions are very important.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method