Category: 27828-71-3

Li, Yun-xia; Xia, Yan; Lu, Ling-zhi; Feng, Yun-long published the article 《Two lead(II)-organic coordination polymers based on N-acetic-5-oxygen-nicotinic acid: syntheses, structures and fluorescence properties》. Keywords: lead coordination polymer fluorescence crystal structure.They researched the compound: 5-Hydroxynicotinic acid( cas:27828-71-3 ).Application In Synthesis of 5-Hydroxynicotinic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:27828-71-3) here.

Two new lead coordination polymers, namely, [Pb4(μ3-O)2L2]n (1), [Pb3(μ4-O)2L]n (2) (H2L = N-acetic-5-oxygen-nicotinic acid) have been prepared by the reaction of Pb(NO3)2 with H2L and characterized by elemental anal., IR and single crystal X-ray diffraction. Polymer 1 crystallizes in the monoclinic C2/c space group, and features [Pb4(μ3-O)2]n rigid inorganic chains, which are further linked by L2- ligands to form a 3D framework. Polymer 2 crystallizes in the orthorhombic P212121 space group, and displays a 3D framework with [Pb3(μ4-O)2]n inorganic chains. The thermodn. stability and fluorescence properties of 2 were investigated. CCDC: 1432217, 1; 1432218, 2.

After consulting a lot of data, we found that this compound(27828-71-3)Application In Synthesis of 5-Hydroxynicotinic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Role of the Tyr270 residue in 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti, published in 2017-02-28, which mentions a compound: 27828-71-3, mainly applied to methylhydroxypyridinecarboxylate oxygenase Mesorhizobium active site tyrosine role; crystal structure methylhydroxypyridinecarboxylate oxygenase Mesorhizobium; 2-Methyl-3-hydroxypyridine-5-carboxylic acid oxygenase; Flavoenzyme; Mesorhizobium loti; Pyridine-ring opening reaction; Tyr270; Vitamin B(6) degradation pathway I, Category: catalyst-palladium.

The flavoenzyme, 2-methyl-3-hydroxypyridine-5-carboxylate oxygenase (MHPCO), catalyzes the cleavage of the pyridine ring of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) in the presence of NADH, O2, and water. MHPCO also catalyzes the NADH oxidation reaction uncoupled with ring opening in the absence of MHPC (the basal activity). The enzyme showed activity toward not only MHPC but also 5-hydroxynicotinic acid (5HN) and 5-pyridoxic acid (5PA). The reaction rate toward 5PA was extremely low (5% of the activity toward MHPC or 5HN). The authors determined the crystal structures of MHPCO without substrate and the MHPCO/5HN and MHPCO/5PA complexes, together with a Y270F mutant without substrate and its 5HN complex. The Tyr-270 residue was located in the active site and formed H-bonds between the Oη atom and water mols. to make the active site hydrophilic. Although Tyr-270 took a fixed conformation in the structures of the MHPCO and MHPCO/5HN complex, it took 2 conformations in its 5PA complex, accompanied by 2 conformations of the bound 5PA. In the wild-type (WT) enzyme, the turnover number of the ring-opening activity was 6800-fold that of the basal activity (1300 and 0.19 s-1, resp.), whereas no such difference was observed in the Y270F (19 and 7.4 s-1) or Y270A (0.05 and 0.84 s-1) mutants. In the Y270F/5HN complex, the substrate bound ∼1 Å farther away than in the WT enzyme. These results revealed that Tyr-270 is essential to maintain the WT conformation, which in turn enhances the coupling of the NADH oxidation with the ring-opening reaction.

After consulting a lot of data, we found that this compound(27828-71-3)Category: catalyst-palladium can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Thermodynamics and Reduction Kinetics Properties of 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase, published in 1997-03-04, which mentions a compound: 27828-71-3, Name is 5-Hydroxynicotinic acid, Molecular C6H5NO3, Application of 27828-71-3.

The investigation by absorbance and fluorescence rapid reaction spectrophotometry of the binding of the substrate MHPC (2-methyl-3-hydroxypyridine-5-carboxylic acid) or the substrate analog 5HN (5-hydroxynicotinic acid) to the flavoprotein MHPCO (2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase) shows that the binding proceeds in two steps. An enzyme-substrate complex initially formed is followed by a ligand-induced isomerization. This binding process is required for efficient reduction of the enzyme-bound flavin, as evidenced by the fact that MHPCO-substrate complexes can be reduced by NADH much faster than the enzyme alone. Since redox potential values of MHPCO and MHPCO-substrate complexes are the same, steric factors, such as the relative orientation of MHPC to the enzyme-bound flavin, are important for efficient hydride transfer to occur.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, P.H.S., Biochemistry called Reaction of 2-Methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) Oxygenase with N-Methyl-5-hydroxynicotinic acid: Studies on the Mode of Binding, and Protonation Status of the Substrate, Author is Chaiyen, Pimchai; Brissette, Pierre; Ballou, David P.; Massey, Vincent, which mentions a compound: 27828-71-3, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3, Quality Control of 5-Hydroxynicotinic acid.

Titrations of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase with the substrate MHPC identified the MHPC species bound to the enzyme as the tripolar ionic species. This result was supported by studies of the binding to the enzyme of N-methyl-5-hydroxynicotinic acid (NMHN), an MHPC analog existing only in the tripolar ionic form. The Kd is 55 μM compared to a Kd of 9.2 μM for MHPC and 5.2 μM for 5-hydroxynicotinic acid (5HN). Kinetics studies of the binding of NMHN to MHPC oxygenase show that its binding, like that for MHPC and for 5HN, is also a two-step process. Since NMHN never exists as an anionic form, neither of the observed steps is due to the binding of an anionic species as an intermediate step. Investigations of the reduction and oxygenation half reactions demonstrate that the mechanism of catalysis with NMHN is basically the same as with MHPC or with 5-hydroxynicotinic acid. Product anal. from reactions using NMHN, a compound that possesses pos. charge on the nitrogen atom, indicates that the product of NMHN is an aliphatic compound, similar to the products derived from MHPC and from another substrate analog, 5-hydroxynicotinic acid. These results indicate that the nitrogen atom of the substrate is invariably protonated during the catalytic reaction.

The article 《Reaction of 2-Methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) Oxygenase with N-Methyl-5-hydroxynicotinic acid: Studies on the Mode of Binding, and Protonation Status of the Substrate》 also mentions many details about this compound(27828-71-3)Quality Control of 5-Hydroxynicotinic acid, you can pay attention to it, because details determine success or failure

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya called Structure of β-hydroxy derivatives of monopyridinecarboxylic acids, Author is Grachev, V. T.; Zaitsev, B. E.; Stolyarova, L. G.; Smirnov, L. D.; Dyumaev, K. M., which mentions a compound: 27828-71-3, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3, Product Details of 27828-71-3.

The UV spectra of the pyridinemonocarboxylic acids, their 5-hydroxy derivatives (and the Et esters of these), and 5-butoxypicolinic and 6-butoxynicotinic acid were determined in neutral, acid, and basic media. The IR spectra of some of these [and of 3-hydroxyisonicotinic acid (I) and its Et ester] were also determined (crystalline). The 5-OH analogs underwent ionization at the CO2H group and formed intermol. H bonds; I existed only partially in the ionized state and formed intramol. H bonds.

The article 《Structure of β-hydroxy derivatives of monopyridinecarboxylic acids》 also mentions many details about this compound(27828-71-3)Product Details of 27828-71-3, you can pay attention to it, because details determine success or failure

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Anomalous cyclization of diethyl 4,4-diethoxy-2-formylglutarate with ammonia》. Authors are Mangoni, Lorenzo.The article about the compound:5-Hydroxynicotinic acidcas:27828-71-3,SMILESS:O=C(O)C1=CN=CC(O)=C1).Related Products of 27828-71-3. Through the article, more information about this compound (cas:27828-71-3) is conveyed.

cf. CA 51, 6600i. The title ester (I) (3.0 g.) cyclized according to Jones (CA 50, 6429c) with NH3 and concentrated H2SO4, the mixture hydrolyzed by boiling 3 hrs. with alc. KOH, the solvent evaporated, the residue taken up in H2O, acidified with concentrated HCl and extracted repeatedly with Et2O gave 2,4-pyrroledicarboxylic acid (II). I (3.8 g.) in 10 ml. dry Et2O kept 10 min. with 5 ml. alc. containing 10% dry NH3, the solvent evaporated in vacuo, and the residue boiled 10 min. in 12 ml. AcOH with 1 g. (NH4)2CO3, the cooled mixture poured into excess ice and Na2CO3, the oily product extracted with Et2O, the washed and dried extract concentrated and the chilled concentrate diluted with petr. ether, filtered from the crystalline product and the filtrate evaporated gave 1.4 g. brown oil, containing II. The air-dried crystalline product (0.85 g.) sublimed at 150° in vacuo and crystallized from ligroine gave Et 3-ethoxy-2(1H)-pyridone-5-carboxylate (III), m. 109-10°, λ 280 mμ (log ε 4.03), giving no color with alc. FeCl3 and no Ehrlich reaction, evolving NH3 copiously on boiling with alc. KOH. III (0.40 g.) heated 20 min. at 130° with 0.25 ml. POCl3 and a trace of dry C5H5N, the cooled mixture treated with ice and filtered, the H2O-washed and dried product sublimed at 100° in vacuo gave Et 6-chloro-5-ethoxynicotinate (IV), m. 34-5°, reprecipitated from solution in concentrated HCl. IV (1.15 g.) in MeOH hydrogenated with 0.30 g. Pd-C 20 hrs. and the filtered solution evaporated gave 1.10 g. hygroscopic ester HCl salt, which refluxed 1.5 hrs. with 10 ml. 2N NaOH and 5 ml. alc., the alc. evaporated in vacuo and the residue acidified cautiously to Congo red gave 5-ethoxynicotinic acid, m. 191-2° (MeOH). The acid (0.15 g.) refluxed 3 hrs. with 3 ml. HBr (d. 1.48), the excess HBr evaporated in vacuo and the residue taken up in a min. of H2O, adjusted to pH 4.5-5.0 with 2N NaOH and the washed and dried precipitate crystallized from H2O gave 5-hydroxynicotinic acid monohydrate, m. 293-4° (decomposition), giving a reddish orange color with alc. FeCl3.

The article 《Anomalous cyclization of diethyl 4,4-diethoxy-2-formylglutarate with ammonia》 also mentions many details about this compound(27828-71-3)Related Products of 27828-71-3, you can pay attention to it, because details determine success or failure

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Joseph, Abhinav; Rodrigues Alves, Joana S.; Bernardes, Carlos E. S.; Piedade, M. Fatima M.; Minas da Piedade, Manuel E. published an article about the compound: 5-Hydroxynicotinic acid( cas:27828-71-3,SMILESS:O=C(O)C1=CN=CC(O)=C1 ).COA of Formula: C6H5NO3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:27828-71-3) through the article.

The importance of controlling the crystallization of mols. in specific conformations for the production of crystalline organic materials with highly reproducible physicochem. properties has long been recognized. Using 5-hydroxynicotinic acid (5HNA) as a model the following two questions were addressed in this work: (i) is it possible to promote the crystallization of a tautomeric form dominant in a specific solvent through solvate formation (ii) Does that form persist if the memory of solvation is erased through thermal desolvation. Single crystal X-ray diffraction (SCXRD) anal. indicated that the crystallization of 5HNA from water and DMSO do indeed lead to a monohydrate, 5HNA.H2O, and a monosolvate, 5HNA.DMSO, resp., where the tautomeric form preferred in solution is preserved (zwitterionic in H2O and neutral in DMSO). Subsequent differential scanning calorimetry (DSC), thermogravimetry (TG), powder X-ray diffraction (PXRD), and diffuse reflectance IR Fourier transform (DRIFT) spectroscopy studies indicated that: (i) albeit upon thermal desolvation different solid forms are initially produced, their structures converge over time to that of the 5HNA starting material, hence to a crystal lattice consisting of the same tautomer; (ii) this tautomer corresponds to a zwitterion. The hydrate and solvate forms showed very distinct solvent loss behaviors at 298 K: 5HNA.H2O did not undergo dehydration even when kept under a reduced pressure, while 5HNA.DMSO was only stable for long periods of time if stored in a closed vial. A thermodn. anal. based on DSC and Calvet drop microcalorimetry results allowed to rationalize these observations indicating that: (i) 5HNA.H2O is predicted to spontaneously lose water, even for a relative humidity of 100%, hence its robustness is most certainly of kinetical origin; (ii) 5HNA.DMSO is thermodynamically stable when a saturation DMSO pressure can be established over the sample, but becomes unstable when exposed to an atm. where the solvent is absent. The kinetically easier desolvation of 5HNA.DMSO compared to 5HNA.H2O may be related to the fact that water is isolated in the crystal lattice (isolated site hydrate) while DMSO is placed in channels (channel solvate).

After consulting a lot of data, we found that this compound(27828-71-3)COA of Formula: C6H5NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Quality Control of 5-Hydroxynicotinic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about A new synthesis of calcium N-(5-hydroxynicotinoyl)-L-glutamate and its X-ray diffraction structure. Author is Kiselev, A. V.; Machula, A. A.; Efimov, S. I.; Pashkova, E. B.; Stovbun, S. V..

A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction anal. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Hydroxy- and amino-substituted piperidinecarboxylic acids as γ-aminobutyric acid agonists and uptake inhibitors, published in 1982, which mentions a compound: 27828-71-3, Name is 5-Hydroxynicotinic acid, Molecular C6H5NO3, Reference of 5-Hydroxynicotinic acid.

The syntheses of (3RS,4RS)-4-hydroxypiperidine-3-carboxylic acid, (3RS,5SR-5-hydroxypiperidine-3-carboxylic acid, (3RS,4SR)-4-acetamidopiperidine-3-carboxylic acid and (3RS,5SR)-5-acetamidopiperidine-3-carboxylic acid, related to the specific γ-aminobutyric acid (GABA) uptake inhibitors (RS)-piperidine-3-carboxylic acid (nipecotic acid) and (3RS,5SR)-4-hydroxypiperidine-3-carboxylic acid, are described. (3RS,4SR)-3-Hydroxypiperidine-4-carboxylic acid, related to the specific GABA agonist piperidine-4-carboxylic acid (isonipecotic acid), has been synthesized. The affinity of the compds for the GABA receptors and for the neuronal (synaptosomal) GABA uptake system in vitro has been measured.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro, the main research direction is Amino acid oxidase inhibitor screening.Name: 5-Hydroxynicotinic acid.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method