Category: 438565-33-4

Zheng, Ran; Feng, Fan; Zhang, Zhihui; Fu, Jiaxu; Su, Qing; Zhang, Yumin; Gu, Qiang published an article about the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4,SMILESS:OCC1=CC(C2=CC=CC=C2Cl)=NO1 ).Related Products of 438565-33-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:438565-33-4) through the article.

An efficient strategy for synthesizing of 3-substituted bis-isoxazole ether bearing 2-chloro-3-pyridyl under microwave radiation was reported. The reactive regioselectivity was improved by changing mainly the solvent and acid-binding agent. 3-(2-Chloropyridin-3-yl)-5-(((3-substituted Ph isoxazol-5-yl)methoxy)methyl)isoxazoles were synthesized in 31-92% yields and were characterized by FT-IR, HRMS, 1H and 13C NMR spectroscopy. The single crystal of 3-(2-chloropyridin-3-yl)-5-(((3-(p-tolyl)isoxazol-5-yl)methoxy)methyl)isoxazole was obtained and the structure of compound was also determined by X-ray diffraction technique. Weak intra- and intermol. C-H···O interactions and a C-H···π interaction link mols. into a three-dimensional network. The results showed that the synthesized compounds belonged to triclinic system, and their regioselectivity depended on the solvent and acid-binding agent. The merits of this method include the environmentally friendly, efficient, simple operation, and higher regional selectivity. An efficient synthesis of 3-substituted bis-isoxazole ethers was developed via 1,3-dipolar cycloaddition reaction starting from 3-substituted phenyl-5-((prop-2-yn-1-yloxy)methyl)isoxazoles and (Z)-2-chloro-N-hydroxynicotinimidoyl chloride using NaHCO3 as an acid-binding agent in THF solvent-dissolved trace water under catalyst-free microwave-assisted conditions.

This compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Related Products of 438565-33-4 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about An efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation. Author is Zhang, Dawei; Chen, Xiaodong; Guo, Xue; Zhang, Yumin; Hou, Yaya; Zhao, Tianqi; Gu, Qiang.

An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, Et acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86-96 %), and were characterized by HRMS, FTIR, 1H NMR, and 13C NMR spectroscopy. Solid support SiO2 possesses favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO2. Moreover, the crystal structure of compound di-Et 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented.

This compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Datong; Jia, Jiong; Meng, Lijuan; Xu, Weiren; Tang, Lida; Wang, Jianwu researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.They published the article 《Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings》 about this compound( cas:438565-33-4 ) in Archives of Pharmacal Research. Keywords: butyl succinate hydroxamate isoxazole derivative preparation SAR antibacterial activity. We’ll tell you more about this compound (cas:438565-33-4).

Two series of novel 2-Bu succinate-based Hydroxamate derivatives containing isoxazole rings, e.g. I [R = H, i-Bu], were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcusaureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

This compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yong, Jian-Ping; Lu, Can-Zhong; Wu, Xiaoyuan researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol.They published the article 《Potential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity》 about this compound( cas:438565-33-4 ) in Anti-Cancer Agents in Medicinal Chemistry. Keywords: cancer cell isoxazole quinazoline anticancer agent. We’ll tell you more about this compound (cas:438565-33-4).

14 New structures of isoxazole-moiety-containing quinazoline derivatives(3a∼3n) were synthesized for the first time and characterized by IR, 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, most compounds showed good to excellent anticancer activity, especially 3d, 3i, 3k and 3m exhibited the more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising drug candidates for development of anticancer drugs.

The article 《Potential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity》 also mentions many details about this compound(438565-33-4)Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Synthetic Route of C10H8ClNO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Synthesis of isoxazole moiety containing ferrocene derivatives and preliminarily in vitro anticancer activity. Author is Yong, Jianping; Lu, Canzhong; Wu, Xiaoyuan.

Seven isoxazole-ring-containing ferrocene derivatives were synthesized and characterized by 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116, and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, ferrocenecarboxylic acid 3-(2-chlorophenyl)isoxazol-5-ylmethyl ester (3d) exhibited wide spectrum anticancer activity and is the most potent among the isoxazole-ring-containing ferrocene derivatives Compound 3d is more active against A549 and HCT116 cell lines (IC50s: 0.747 and 3.65 nM, resp.) than the reference drug gefitinib (IC50s: 17.90 and 21.55 μM, resp.). 3D can be seen as the best candidate for development of anticancer drugs.

The article 《Synthesis of isoxazole moiety containing ferrocene derivatives and preliminarily in vitro anticancer activity》 also mentions many details about this compound(438565-33-4)Synthetic Route of C10H8ClNO2, you can pay attention to it, because details determine success or failure

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Related Products of 438565-33-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Synthesis and Biological Evaluation of Quinazoline Derivatives as Potential Anticancer Agents (II).

Under the guidance of our previous work, we synthesized 21 new structures of quinazolines (3a∼3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines using the MTT method. Most compounds showed good to excellent anticancer activity. In particular, 3o (regarded as erlotinib analogs) has marked anticancer activity against A549, HCT116 and MCF-7 cell lines (IC50s: 4.26, 3.92 and 0.14 M, resp.) as compared with the standard anticancer drug gefitinib (IC50s: 17.9, 21.55 and 20.68 M, resp.), and which can be regarded as the best candidate for development of anticancer drugs.

After consulting a lot of data, we found that this compound(438565-33-4)Related Products of 438565-33-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Ultrasonics Sonochemistry called Ultrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition, Author is Zhang, Da-wei; Zhang, Yu-min; Li, Jing; Zhao, Tian-qi; Gu, Qiang; Lin, Feng, which mentions a compound: 438565-33-4, SMILESS is OCC1=CC(C2=CC=CC=C2Cl)=NO1, Molecular C10H8ClNO2, Application In Synthesis of 3-(2-Chlorophenyl)-5-isoxazolemethanol.

An efficient synthesis of 1,4-disubstituted 1,2,3-triazole derivatives I (R = C6H5, 2-ClC6H4, 3-O2NC6H4, etc.) and II was studied. 1,4-Disubstituted 1,2,3-triazoles containing isoxazole and thymidine structures were synthesized in 84-96% yields starting from various terminal isoxazole ether alkynes and β-thymidine azide derivatives via a 1,3-dipolar cycloaddition using copper acetate, sodium ascorbate as the catalyst under ultrasonic assisted condition. Furthermore, the quorum sensing inhibitory activities of synthesized compounds were evaluated with Chromobacterium violaceum (C. Violaceum CV026) based on their inhibition of violacein production, with compound C10-HSL as a pos. control. The compounds II (R = C6H5, 4-ClC6H4,and 4-C(CH3)3C6H4) exhibited considerable levels of inhibitory activity against violacein production, and IC50 values were 217 +/- 19, 223 +/- 20 and 42.8 +/- 4.5 μM, resp., which highlighted the potential of these compounds as lead structures for further research towards the development of novel QS inhibitors.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ) is researched.Computed Properties of C10H8ClNO2.Shen, Chuansheng; Zhang, Yumin; Gan, Yuanming; Zhao, Tianqi; Gu, Qiang published the article 《One-pot synthesis of (3-phenylisoxazol-5-yl)methanol derivatives under ultrasound》 about this compound( cas:438565-33-4 ) in Letters in Organic Chemistry. Keywords: aldoxime propargyl alc dipolar cycloaddition ultrasound; phenylisoxazolyl methanol preparation ultrasonication. Let’s learn more about this compound (cas:438565-33-4).

An ultrasonic-assisted, one-pot, efficient, convenient procedure for the synthesis of (3-phenylisoxazol-5-yl)methanol derivatives was developed. (3-Phenylisoxazol-5-yl)methanol derivatives with biol. and pharmaceutical property were synthesized in moderate to excellent yields. The synthetic methods possess the advantages of high yield, facile operation process and shorter reaction time, and so on.

In addition to the literature in the link below, there is a lot of literature about this compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Computed Properties of C10H8ClNO2, illustrating the importance and wide applicability of this compound(438565-33-4).

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Formula: C10H8ClNO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Efficient synthesis of bis-isoxazole ethers via 1,3-dipolar cycloaddition catalysed by Zn/Zn2+ and their antifungal activities. Author is Zhang, Da-Wei; Lin, Feng; Li, Bo-Chao; Liu, Hong-Wei; Zhao, Tian-Qi; Zhang, Yu-Min; Gu, Qiang.

A series of novel bis-isoxazole ether compounds I [R = 3-pyridyl, 3-O2NC6H4, 4-O2NC6H4, 4-(H3C)3CC6H4; R1 = 4-C(CH3)3, 3-NO2, (Z)-CH=CHC6H5, etc.] were synthesized starting from different substituted aldehydes RCHO and R1CHO via 1,3-dipolar cycloaddition using Zn/Zn2+ as a catalyst. In addition, the antimicrobial properties of synthesized products were investigated. The synthesized compounds I exhibited significant antifungal activities in comparison with the standard drugs, fluconazole and itraconazole. It was found that Candida albicans was sensitive to 2-substituted Ph bis-isoxazole ethers bearing pyridyl I [R1 = 2-OCH3, 2-Cl].

In addition to the literature in the link below, there is a lot of literature about this compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Formula: C10H8ClNO2, illustrating the importance and wide applicability of this compound(438565-33-4).

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ) is researched.Electric Literature of C10H8ClNO2.Yin, L.; Jia, J.; Zhao, G. L.; Xu, W. R.; Tang, L. D.; Wang, J. W. published the article 《Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors》 about this compound( cas:438565-33-4 ) in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. Keywords: formyl hydroxylamine preparation antibacterial peptide deformylase inhibitor. Let’s learn more about this compound (cas:438565-33-4).

N-formylhydroxylamines RC(NH2):COCH2NHCOCHBuCH2N(OH)CHO (R = substituted Ph) were synthesized through a multi-step protocol starting from H2C(CO2Et)2. The newly synthesized compounds were screened for antibacterial activity. All the compounds exhibited potent in-vitro inhibitory activity against S. aureus and weak activity against K. pneumoniae.

There are many compounds similar to this compound(438565-33-4)Electric Literature of C10H8ClNO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method