Category: 438565-33-4

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hu, Dejin; Liu, Sufang; Huang, Tonghui; Tu, Haiyang; Li, Weiguo; Zhu, Xiaolei; Zhang, Aidong researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Application of 438565-33-4.They published the article 《Synthesis and herbicidal activities of Nε-[(anilino)carbonyl]-Nα-[(3-phenyl-5-isoxazolyl)carbonyl]lysine》 about this compound( cas:438565-33-4 ) in Youji Huaxue. Keywords: D1 protease inhibitor herbicide isoxazole lysine preparation. We’ll tell you more about this compound (cas:438565-33-4).

Recently the D1 protease located in the thylakoid membranes of higher plants was found to be a potential herbicide target and based on a lead compound [Nα-[(5-isoxazolyl)carbonyl]lysine, D1 protease inhibitor] a series of novel N5-[(phenylamino)carbonyl]-N2-[(3-phenyl-5-isoxazolyl)carbonyl]lysine derivatives were designed. The synthesis of the target compounds was achieved using as reactants 3-phenyl-5-isoxazolecarbonyl chlorides and N5-[(phenylamino)carbonyl]lysine and the products thus obtained were confirmed by IR, 1H-NMR and elemental anal. The biol. activity was examined in vivo and it was discovered that most compounds possessed moderate herbicidal activity. Meanwhile, the e activity of one compound was evaluated against spinach D1 protease (i.e., thylakoid protein precursor processing peptidase, chloroplast protein precursor-processing proteinase, photosystem D1 protein precursor carboxyl-terminal processing proteinase, proteinase CtpA) and the result showed its inhibiting effect against this enzyme.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Reference of 3-(2-Chlorophenyl)-5-isoxazolemethanol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Soluble polymer-supported synthesis of isoxazoles. Author is Shang, Yong-Jia; Wang, Yan-Guang.

The first soluble polymer-supported synthesis of isoxazoles through a 1,3-dipolar cycloaddition is described. A soluble polymer-supported alkyne reacts with nitrile oxides generated in situ to give isoxazoles in good yield.

There are many compounds similar to this compound(438565-33-4)Reference of 3-(2-Chlorophenyl)-5-isoxazolemethanol. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Wang, Xi-Zhao; Jia, Jiong; Zhang, Yan; Xu, Wei-Ren; Liu, Wei; Shi, Fang-Niu; Wang, Jian-Wu published the article 《Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins》. Keywords: isoxazole penicillin derivative preparation antibacterial amidation dipolar cycloaddition.They researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:438565-33-4) here.

The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C6H4-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO2, -4-NO2, -3-CF3, -4-CF3, C6H3-2,4-Cl2, -3,4-Cl2, C6H2-2,4,5-Cl3, -3,4,5-Cl3, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH2OH using CuSO4.5H2O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Wang, Xi-Zhao; Jia, Jiong; Zhang, Yan; Xu, Wei-Ren; Liu, Wei; Shi, Fang-Niu; Wang, Jian-Wu published the article 《Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins》. Keywords: isoxazole penicillin derivative preparation antibacterial amidation dipolar cycloaddition.They researched the compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol( cas:438565-33-4 ).Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:438565-33-4) here.

The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C6H4-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO2, -4-NO2, -3-CF3, -4-CF3, C6H3-2,4-Cl2, -3,4-Cl2, C6H2-2,4,5-Cl3, -3,4,5-Cl3, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH2OH using CuSO4.5H2O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.

I hope my short article helps more people learn about this compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol. Apart from the compound(438565-33-4), you can read my other articles to know other related compounds.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol(SMILESS: OCC1=CC(C2=CC=CC=C2Cl)=NO1,cas:438565-33-4) is researched.SDS of cas: 18436-73-2. The article 《Synthesis of isoxazolines and isoxazoles using poly(ethylene glycol) as support》 in relation to this compound, is published in Synthesis. Let’s take a look at the latest research on this compound (cas:438565-33-4).

A general method for the liquid-phase syntheses of isoxazoles and isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkyne or alkene reacted with nitrile oxides generated in situ from aldoximes, followed by cleavage from the PEG, to give isoxazoles or isoxazolines in good yield and purity.

This literature about this compound(438565-33-4)Formula: C10H8ClNO2has given us a lot of inspiration, and I hope that the research on this compound(3-(2-Chlorophenyl)-5-isoxazolemethanol) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Computed Properties of C10H8ClNO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Synthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II). Author is Yong, Jianping; Lu, Canzhong; Wu, Xiaoyuan.

New structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives I (R1 = Me, Ph; R2 = H, Me; R3 = H, Ph; R4 = H, 4-Me, 4-MeO, etc.) were synthesized for the first time and their in vitro anticancer activity against lung cancer A549, colorectal HCT116 and breast cancer MCF-7 cell lines was preliminarily evaluated using the MTT method. Most of the compounds exhibited good to excellent anticancer activity. In particular, I (R1 = Me; R2, R3 = H; R4 = Br), I (R1, R3 = Ph; R2 = H; R4 = 4-MeO) and I (R1, R3 = Ph; R2 = H; R4 = 4-Br) exhibited a broad spectrum and more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising anticancer drug-candidates.

From this literature《Synthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II)》,we know some information about this compound(438565-33-4)Computed Properties of C10H8ClNO2, but this is not all information, there are many literatures related to this compound(438565-33-4).

Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation.COA of Formula: C10H8ClNO2.

An efficient synthesis of bis(indolyl)methanes I (R1 = C6H5, 3-pyridinyl, 4-CH3C6H4, etc.) was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98%). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring II (R2 = H, t-Bu, 4-Cl, etc.) were synthesized via this method in excellent yields (> 94%) using 3-substituted isoxazole-5-carbaldehydes and indole.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Reference of 3-(2-Chlorophenyl)-5-isoxazolemethanol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Design, Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group. Author is Feng, Fan; Li, Jing; Zhang, Zhihui; Fu, Jiaxu; Zhang, Yumin; Gu, Qiang.

An ultrasonic-assisted synthesis of bis-isoxazole derivatives was developed. Eight 3-(6-chloropyridin-3-yl)-5-{[(3-arylisoxazol-5-yl)methoxy]methyl}isoxazoles I [R1 = H, 4-Me, 2-Cl, etc.] were synthesized by 1,3-dipolar cycloaddition reaction between substituted isoxazolyl alkyne compounds and 6-chloro-N-hydroxynicotinimidoyl chloride. The structures of the synthesized compounds were confirmed by HRMS, FTIR, 1H and 13C NMR spectroscopy. Wherein, the antifungal and antibacterial activities of target compounds were tested. The synthesized compounds I [R1 = 2-methoxy, 2-Cl] exhibited better antifungal activity in comparison with the standard drug itraconazole. The min. inhibitory concentrations(MICs) of compound I [R1 = 2-methoxy, 2-Cl] were both 4μg/mL against Candida albicans ATCC 10231.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method