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The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 52409-22-0, name is Pd2(DBA)3, introducing its new discovery. Formula: C51H42O3Pd2

We report the synthesis of a series of A1?pi?A2?pi?A1-type small molecules, DPP2T-RH, DPPFT-RH, and DPPT-RH, in which thiophene and furan were introduced to bridge the two strong electron-withdrawing units of DPP and rhodanine (RH). Interestingly, these DPP-RH-based small molecules exhibited ambipolar characteristics, showing photovoltaic performance both as donors and acceptors in combination with PC71BM and P3HT, respectively. The best power conversion efficiencies were obtained from DPPFT-RH (1.77%) and DPP2T-RH (1.28%) as donor and acceptor, respectively. Their physical properties, film packing ability, and photovoltaic performances were fine-tuned by rational design of the pi-bridges.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Diversity-oriented synthesis of fused tetracyclic 6,11- dihydroquinoxalino[2,3-b]quinolines is described via a sequential Ugi-variant multicomponent reaction and Pd-catalyzed bis-annulation in one-pot process.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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52409-22-0, Name is Pd2(DBA)3, belongs to catalyst-palladium compound, is a common compound. Product Details of 52409-22-0In an article, once mentioned the new application about 52409-22-0.

A palladium-catalyzed C(sp2)-H difluoromethylation of aldehyde-derived hydrazones using bromodifluoromethylated compounds to afford the corresponding functionalized difluoromethylketone hydrazones has been established. It is proposed that a radical/SET mechanism proceeding via a difluoroalkyl radical may be involved in the catalytic cycle. Applications of the methodology to the synthesis of alpha,alpha-difluoro-beta-ketoesters and alpha,alpha-difluoroketones (RCOCF2H) have been illustrated.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Enantioselective conjunctive cross-coupling with propargylic carbonates affords beta-boryl allenes as the reaction product. The reaction is found to proceed through the intermediacy of dimethoxyboronate complexes that are generated in situ by a strain-induced ligand exchange reaction.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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A new random conjugated terpolymer, coded as LGC-D054, was designed and synthesized. It is composed of N-alkylthieno[3,4-c]pyrrole-4,6-dione (TPD) as an electron-accepting unit, and benzodithiophene (BDT) and terthiophene as electron-donating units into the polymer backbone. The optical, electrochemical, and photovoltaic properties of the terpolymer were investigated. The polymer displayed an optical bandgap of 1.81 eV, with a highest occupied molecular orbital (HOMO) level of ?5.25 eV. The bulk-heterojunction (BHJ) polymer solar cell (PSC) with the blend film based on LGC-D054:PC71BM exhibited a power conversion efficiency (PCE) of 4.46% with the short circuit current density (Jsc) of 8.71 mA/cm2 and a relatively high fill factor (FF) of 61.21%. After introducing 1,8-diiodooctane (DIO), BHJ film showed better phase separation and larger domain size. Furthermore, this optimized morphology promotes improved hole and electron mobilities, leading to a promising PCE of 5.08% with improved Jsc of 9.08 mA/cm2 and high FF of 66.02%.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer’s disease.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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We report two banana-shaped organic semiconducting small molecules containing the relatively unexplored thieno[3,2-b]pyrrole with thiophene and furan flanked benzothiadiazole. Theoretical insights gained by DFT calculations, supported by single crystal structures show that furan flanked benzothiadiazole-thieno[3,2-b]pyrrole small molecule has a higher curvature compared to the thiophene flanked small molecule due to the shorter carbon-oxygen bond in furan. Despite similar optical and electrochemical properties, thiophene flanked small molecule shows average hole mobility up to 8 × 10-2 cm2 V-1 s-1, however furan flanked small molecule performs poorly in thin film transistor devices (muh ? 5 × 10-6 cm2 V-1 s-1). The drastic difference in hole mobilities was due to the annealing-induced crystallinity which was demonstrated by the out-of-plane grazing incidence X-ray diffraction and surface morphology studies by tapping mode atomic force microscopy analysis.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C51H42O3Pd2. Introducing a new discovery about 52409-22-0, Name is Pd2(DBA)3

The construction of alpha-(hetero)aryl ethenesulfonyl fluorides was achieved via a Pd-catalyzed Suzuki coupling of arylboronic acids with 1-bromoethene-1-sulfonyl fluoride (1-Br-ESF). The novel alpha-aryl ethenesulfonyl fluorides were found to be another selectively addressable bis-electrophile for wide diversification through SuFEx click chemistry, or Michael addition with excellent chemical discrimination.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Two hole transport materials with high glass transition temperatures (Tg ~ 200 C) have been synthesized by replacing the phenyl groups of 4,4?-bis[N-(1-naphthyl-1)-N?-phenyl-amino]-biphenyl (alpha-NPD) with the bulkier phenanthrene (N,N?-di(naphthalene-1-yl)-N, N?-di(phenanthrene-9-yl)biphenyl-4,4?-diamine, NPhenD) or anthracene (N,N?-di(anthracene-9-yl)-N,N?-di(naphthalene-1-yl)biphenyl-4, 4?-diamine, NAD). The organic light-emitting diodes (OLEDs) using these hole transport materials exhibited stable operation at high temperatures up to 420 K, improved device lifetimes, and reduced operating voltage changes compared to the conventional hole transport materials owing to their high Tg. Although NAD has quite small bandgap as a hole transport material, superior thermal properties of NPhenD and NAD suggest that they can be promising materials for highly stable and high temperature-durable OLEDs and other organic optoelectronic devices.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method