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The present invention relates to compounds of general formula I, wherein the group R1, R2, X, Y and z are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The invention provides a low-temperature quick preparation of 2, 2 – di (4 – (4 – aminophenoxy) phenyl) hexafluoropropane of intermediates, the 2, 2 – di (4 – (4 – aminophenoxy) phenyl) hexafluoropropane midbody is 2, 2 – di (4 – (4 – nitrophenoxy) phenyl) hexafluoropropane, the 2, 2 – di (4 – hydroxyphenyl) hexafluoropropane and para-halogenated nitrobenzene in solvent, catalyst A and alkali the existence of a reaction, be 2, 2 – di (4 – (4 – nitrophenoxy) phenyl) hexafluoropropane. The invention also provides low temperature for rapid preparation of 2, 2 – di (4 – (4 – aminophenoxy) phenyl) hexafluoropropane. The invention uses low temperature operation, 65 – 80 C lower reaction 8 hours can complete the preparation of the intermediate compound; the method of the invention can improve the product yield, the yield is 78% or more; at the same time can reduce the production cost. (by machine translation)

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The Pd-catalyzed annulations of ortho-halide-containing benzyl alcohols with alkynes for the synthesis of indenones were achieved in aqueous Triton X-100 micelles with good yields and wide substrate scopes. Moreover, the indenones obtained in this procedure can be further functionalized to form some more synthetic useful derivatives via an environmental-friendly way.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Related Products of 887919-35-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.887919-35-9, Name is Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II), molecular formula is C32H56Cl2N2P2Pd. In a article,once mentioned of 887919-35-9

The invention discloses two chlorine two uncles butyl – 4 – dimethyl amino […] preparation method, comprises the following steps: step 1, using raw materials N, N – dimethyl skating aniline and splicing preparation Grignard reagent; step 2, takes standard reagent and the temperature, and then adding the catalyst after-reaction, then dropwise di-tert-butyl chloride, to obtain the temperature of the after-reaction of di-tert-butyl – 4 – dimethyl amino phosphonate; step 3, to the di-tert-butyl – 4 – dimethyl amino phosphonate purification processing; step 4, taking double-(acetonitrile) palladium dichloride with purified di-tert-butyl – 4 – dimethyl amino phosphonate to the complexation reaction, to obtain the target product. The preparation method of the present invention to di-tert-butyl – 4 – dimethyl amino phosphonate to carry out purification process, high purity of di-tert-butyl – 4 – dimethyl amino phosphonate with double-(acetonitrile) palladium dichloride reaction, thereby greatly reducing the noble metal palladium yield losses, the preparation cost is greatly reduced, there is very good practical value. (by machine translation)

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The invention relates to compounds of formula (I): (I) useful for treating disorders mediated by acyl coA-diacylgly- cerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Two practical entries to arylomycin antibiotics core structures are investigated. In route A, the activation of l-Hpg for the key macrolactamization step is achieved in 89% yield in the presence of unprotected phenol and amine functionalities. Alternatively, a propanephosphonic acid anhydride (T3P)-promoted coupling between thel-Tyr and l-Ala moieties in route B led to a facile macrolactamization in 68% yield with a marked reduction in competing oligomerization.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of RORgamma and the treatment of diseases related to the modulation of RORgamma. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I):wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Two Pd-catalyzed methods to access 6-heteroaryl 2-aminopurine ribonucleosides from 6-chloroguanosine are described. First, Pd-132-catalyzed Suzuki-Miyaura cross-coupling using a series of boron substrates and 6-chloroguanosine forms 6-heteroaryl-2-aminopurines in a single step. The versatility of 6-chloroguanosine is further demonstrated using a modified Sonogashira coupling employing potassium iodide as an additive. Finally, the utility of the 6-alkynyl-2-aminopurine ribonucleoside as a dipolarophile in [3 + 2] cycloadditions is presented, affording triazoles and isoxazoles when reacted with azide and isonitrile 1,3-dipoles, respectively.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladiumcatalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50%is a large improvement over the single, previous synthesis. By design, this modular route allows the rapid synthesis of other members of the protoberberine family (e.g., pseudocoptisine and palmatine) by substitution of the readily available aryl bromide and ketone coupling partners. Moreover, by combining enolate arylation with in situ functionalization, substituents can be rapidly and regioselectively introduced at the alkaloid C13 position, as demonstrated by the total synthesis of dehydrocorydaline. The avoidance of electrophilic aromatic substitution reactions to make the isoquinoline allows direct access to analogues possessing more varied electronic properties, such as the fluorine-containing derivative synthesized here.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method