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IMPROVED METHOD FOR THE MANUFACTURE OF 3-[(1S)-1-IMIDAZO[1,2-A]PYRIDIN-6-YLETHYL]-5-(1-METHYLPYRAZOL-4-YL)TRIAZOLO[4,5-B]PYRAZINE AND POLYMORPHIC FORMS THEREOF

This specification generally relates to an improved method for the manufacture of 3-[(lS)-l -imidazo[ 1,2-a]pyridin-6-ylethyl]-5-(l-methylpyrazol-4-yl)triazolo[4,5- bjpyrazine (I), or pharmaceutically acceptable salts thereof; polymorphic forms thereof; and intermediates useful in the manufacture of such compounds and salts thereof. Formula (I).

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Brief introduction of 1,1′-Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex

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Pyridazinedione compounds useful in treating neurological disorders

The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The Absolute Best Science Experiment for 95464-05-4

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Diorganyl tellurides as substrates in Sonogashira coupling reactions under mild conditions

A new method of Sonogashira coupling reactions between diorganyl tellurides and terminal alkynes is reported. The coupling reactions are performed using Pd(dppf)Cl2 as a catalyst, CuI as a co-catalyst in the presence of K2CO3 in DMSO. The reactions are carried out at room temperature and completed within 2 h when phenyl acetylene is used as a terminal alkyne. For aliphatic terminal alkynes, such as 1-hexyne and 1-octyne, an elevated temperature and longer reaction time are needed for the completion of the reactions. This process results in good yields of Sonogashira coupling products which is applicable for diaryl, divinyl and dialkynyl tellurides but not applicable for dialkyl tellurides.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The important role of 1,1′-Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex

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A sydnone cycloaddition route to pyrazole boronic esters

(Chemical Equation Presented) From dipole to diazole! A direct and regioselective route to functionalized pyrazole boronic esters is developed that employs the cycloaddition of alkynylboronates with sydnones. Functionalization of these products by Suzuki coupling and N-deprotection processes highlight the potential synthetic utility of these species.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Palladium-Catalyzed Cross-Coupling Reaction of Alkyltrifluorosilanes with Aryl Halides

A cross-coupling reaction of alkyltrifluorosilanes with aryl halides was achieved using a catalytic amount of tetrakis-(triphenylphosphine)palladium(0) and excess of tetrabutylammonium fluoride (TBAF) at 100C with high chemoselectitvity. Functional groups like nitro, ketone carbonyl, and formyl tolerated the coupling conditions. Because potassium(18-crown-6) alkyltetrafluorosilicates also underwent a cross-coupling reaction in the presence of an additional molar amount of TBAF, the active species of the coupling reaction was assumed to be pentacoordinate silicates. TBAF in excess was considered to be required for trapping the tetrafluorosilane produced in the catalytic cycle of the cross-coupling reaction.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Final Thoughts on Chemistry for 95464-05-4

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Soluble polymer-supported convergent parallel library synthesis.

Soluble polymer-supported convergent synthesis has for the first time been successfully exploited for parallel library synthesis; sub-libraries of tripeptide iodoarenes and arylboronic acids reacted smoothly in a multipolymer PdII-catalyzed Suzuki coupling reaction to generate a library of bisaryl-linked hexapeptides.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Bis-ZnII salphen complexes bearing pyridyl functionalized ligands for efficient organic light-emitting diodes (OLEDs)

Inspired by the emissive features of ZnII complexes based on bis-Schiff base ligands, bis-ZnII salphen complexes bearing pyridyl functionalized ligands have been successfully synthesized. Their photophysical features, electrochemical behavior and electroluminescent (EL) properties have been investigated in detail. The functionalized bis-ZnII salphen complexes can exhibit high thermal stability up to 417 C, and their photoluminescence (PL) spectra show a maximal emission wavelength peak at ca. 565 nm both in solution and PMMA doped films. The PL investigation of the neat films for these functionalized bis-ZnII salphen complexes indicated that the pyridyl functionalized ligands can effectively reduce the degree of molecular aggregation to enhance their emission intensity. Taking advantage of the charge carrier injection/transporting ability of the pyridyl functionalized ligands and their dendritic design, the optimized EL devices fabricated by a simple solution-processing method can achieve a peak luminance (Lmax) of 3589 cd m-2, a maximal external quantum efficiency (etaext) of 1.46%, a maximal current efficiency (etaL) of 4.1 cd A-1 and a maximal power efficiency (etap) of 3.8 lm W-1. These results should afford important instructions for exploiting high performance fluorescent emitters based on dinuclear ZnII complexes.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The important role of 1,1′-Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 95464-05-4, you can also check out more blogs about95464-05-4

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Synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene bridged diphosphine, NUPHOS, via zirconium-mediated reductive coupling of alkynes and diynes: Applications in palladium-catalyzed cross-coupling reactions

The synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene was discussed. Catalyst mixtures based on 1,2,3,4-Ph4-NUPHOS were found to be superior to those based on BINAP, with activities of 6900 and 260 (mol of product) (mol of palladium)-1h-1 respectively. The applications in palladium catalyzed cross-coupling reactions were also discussed.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Some scientific research about 1,1′-Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex

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Bimetallic DppfM(II) (M = Pt and Pd) dithiocarbamate complexes: Synthesis, characterization, and anticancer activity

A series of bimetallic dppfM(II) (dppf = 1,1?-bis (diphenyphosphino) ferrocene; M = Pt and Pd) dithiocarbamate complexes is synthesized and characterized by spectroscopic methods and single-crystal X-ray diffraction. Their antitumor activities in vitro are investigated by MTT assays against four cancer cell lines. The anticancer studies indicate most of the complexes display good to excellent antitumor activity. Remarkably, the platinum complex with a pyrrolidinyl substituent (3b) was identified as the most promising candidate due to its high potency and broad spectrum of activity.

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

More research is needed about 1,1′-Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex

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For skin ulcer care of pyrazolo [1, 5 – a] pyridine drug molecule and its preparation method and application (by machine translation)

The invention discloses a method for skin ulcer care of pyrazolo [1, 5 – a] pyridine drug molecule and its preparation method and application, which belongs to the technical field of medical synthesis. Technical proposal of the invention points are: for skin ulcer care of pyrazolo [1, 5 – a] pyridine pharmaceutical molecular, has the following molecular structure: The invention also specifically discloses the used for skin ulcer care of pyrazolo [1, 5 – a] pyridine pharmaceutical molecular preparation method and can be used for the skin ulcer care in the application of the pharmaceutical composition. The invention integrated sulfur aza compound has sedative, the promotion of growth hormone secretion, anti-ulcer, sterilizing and the like, to synthesize a for skin ulcer care of pyrazolo [1, 5 – a] pyridine pharmaceutical molecular and has carried on the antibacterial activity test, the detection of such compounds to the skin ulcer caused by bacillus anthracis and Staphylococcus aureus better to have inhibitory activity, and then made into pharmaceutical ointment and clinical care experiment, found care effect is more obvious. (by machine translation)

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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method