Name: 5-Hydroxynicotinic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro. Author is Katane, Masumi; Yamada, Shota; Kawaguchi, Go; Chinen, Mana; Matsumura, Maya; Ando, Takemi; Doi, Issei; Nakayama, Kazuki; Kaneko, Yuusuke; Matsuda, Satsuki; Saitoh, Yasuaki; Miyamoto, Tetsuya; Sekine, Masae; Yamaotsu, Noriyuki; Hirono, Shuichi; Homma, Hiroshi.
D-Aspartate oxidase (DDO) is a degradative enzyme that is stereospecific for acidic D-amino acids, including D-aspartate, a potential agonist of the N-methyl-D-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders, such as schizophrenia. Hence, a DDO inhibitor that increases the brain levels of D-aspartate and thereby activates NMDA receptor function is expected to be a useful compound To search for potent DDO inhibitor(s), a large number of compounds were screened in silico, and several compounds were identified as candidates. They were then characterized and evaluated as novel DDO inhibitors in vitro (e.g., the inhibitor constant value of 5-aminonicotinic acid for human DDO was 3.80 μM). The present results indicate that some of these compounds may serve as lead compounds for the development of a clin. useful DDO inhibitor and as active site probes to elucidate the structure-function relationships of DDO.
As far as I know, this compound(27828-71-3)Name: 5-Hydroxynicotinic acid can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method