Related Products of 438565-33-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Synthesis and Biological Evaluation of Quinazoline Derivatives as Potential Anticancer Agents (II).
Under the guidance of our previous work, we synthesized 21 new structures of quinazolines (3a∼3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines using the MTT method. Most compounds showed good to excellent anticancer activity. In particular, 3o (regarded as erlotinib analogs) has marked anticancer activity against A549, HCT116 and MCF-7 cell lines (IC50s: 4.26, 3.92 and 0.14 M, resp.) as compared with the standard anticancer drug gefitinib (IC50s: 17.9, 21.55 and 20.68 M, resp.), and which can be regarded as the best candidate for development of anticancer drugs.
After consulting a lot of data, we found that this compound(438565-33-4)Related Products of 438565-33-4 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method