53199-31-8, Name is Bis(tri-tert-butylphosphine)palladium, belongs to catalyst-palladium compound, is a common compound. category: catalyst-palladiumIn an article, once mentioned the new application about 53199-31-8.
Regio- and Stereoselective Synthesis of 1,1-Diborylalkenes via Br°nsted Base-Catalyzed Mixed Diboration of Alkynyl Esters and Amides with BpinBdan
The NaOtBu-catalyzed mixed 1,1-diboration of terminal alkynes using the unsymmetrical diboron reagent BpinBdan (pin = pinacolato; dan = 1,8-diaminonaphthalene) proceeds in a regio- and stereoselective fashion affording moderate to high yields of 1,1-diborylalkenes bearing orthogonal boron protecting groups. It is applicable to gram-scale synthesis without loss of yield or selectivity. The mixed 1,1-diborylalkene products can be utilized in Suzuki?Miyaura cross-coupling reactions which take place selectivly at the C?B site. DFT calculations suggest the NaOtBu-catalyzed mixed 1,1-diboration of alkynes occurs through deprotonation of the terminal alkyne, stepwise addition of BpinBdan to the terminal carbon followed by protonation with tBuOH. Experimentally observed selective formation of (Z)-diborylalkenes is supported by our theoretical studies.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 53199-31-8
Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method