Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27828-71-3, is researched, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3Conference, Metab. Eff. Nicotinic Acid Its Deriv., Proc. Workshop called Comparison of the effect of nicotinic acid derivatives on in vitro lipolysis and in vivo lipid lowering, Author is Dalton, Colin; Quinn, Janie B.; Crowley, H. J.; Miller, O. Neal, the main research direction is nicotinate lipolysis; fluoronicotinate antilipolysis; cholesterol nicotinate; fatty acid serum nicotinate.Name: 5-Hydroxynicotinic acid.
Nicotinic acid (I) [59-67-6] showed greater in vitro antilipolytic against theophylline [58-55-9]-induced lipolysis in rat isolated fat cells than 20 I derivatives, but some antilipolytic activity was maintained in 8 substituted I derivatives such as 5-fluoronicotinic acid [402-66-4], 5-methylnicotinic acid [3222-49-9], and 5-aminonicotinic acid [24242-19-1]. Compounds active in vitro reduced serum free fatty acids and triglycerides in the fasted rat, and 5-fluoronicotinic acid was 3-4 times more active in this respect than I. I and 5-fluoronicotinic acid lowered serum cholesterol [57-88-5] 24 hr after injection in the fasted rat, and were effective in reducing norepinephrine [51-41-2]-elevated serum free fatty acids and glycerol [56-81-5] levels in the dog, with 5-fluoronicotinic acid having the longer duration of action.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Hydroxynicotinic acid)Name: 5-Hydroxynicotinic acid, illustrating the importance and wide applicability of this compound(27828-71-3).
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method