Reference of 52522-40-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.52522-40-4, Name is Tris(dibenzylideneacetone)dipalladium-chloroform, molecular formula is C52H43Cl3O3Pd2. In a article£¬once mentioned of 52522-40-4
Palladium-catalyzed enantioselective synthesis of carbanucleosides
A general strategy has been developed for enantioselective synthesis of diverse carbanucleosides. The key step is a Pd(0)-catalyzed enantioselective allylic amination of cis-3,5-dibenzoyloxycyclopent-2-ene 10a with the nucleobase. With guanine-derived nucleobase 13 and chiral ligand 9, a 93-96% ee was obtained, while 6-chloropurine and chiral ligand 8 gave 94% ee. The reaction was followed by a second Pd(0)-catalyzed allylic alkylation with phenylsulfonyl(nitro)methane 6. The nitrosulfone, thus obtained, served as a versatile intermediate for divergent synthesis in which the phenylsulfonyl(nitro)methyl group is a surrogate for the hydroxymethyl side chain. With the guanine-derived nucleobase 13, (-)-carbovir was obtained in only four steps from 10a. With 6-chloropurine as an adenine equivalent, the obtained nitrosulfone intermediate 26 could be converted into both (-)- aristeromycin and (-)-neplanocin A as well as their 2′,3′-diepi isomers.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 52522-40-4
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method