Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 14871-92-2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 14871-92-2
Multiple Condensation Reactions Involving PtII/PdII?OH2, Pt?NH3, and Cytosine?NH2Groups: New Twists in Cisplatin?Nucleobase Chemistry
The coordination chemistry of the antitumor agent cisplatin and related complexes with DNA and its constituents, that is, the nucleobases, appears to be dominated by 1:1 and 1:2 adducts of the types cis-[Pta2(nucleobase)X] and cis-[Pta2(nucleobase)2] (a=NH3or amine; a2=diamine or diimine; X=Cl, OH or OH2). Here, we have studied the interactions of the putative 1:1 adducts cis-[Pta2(1-MeC-N3)(OH2)]2+(with a=NH3, a2=2,2?-bpy (2,2?-bipyridine), 1-MeC=model nucleobase 1-methylcytosine) with additional cis-[Pt(NH3)2(OH2)2]2+or its kinetically superior analogues [Pd(en)(OH2)2]2+(en=ethylenediamine) and [Pd(2,2?-bpy)(OH2)2]2+. Depending upon the conditions applied different compounds of different nuclearity are formed. Without exception they represent condensation products of the components, containing mu-1-MeC-H, mu-OH?, as well as mu-NH2?bridges. In the presence of Ag+ions, the isolated products in several cases display additionally Pt?Ag dative bonds. On the basis of the cytosine-containing structures established by X-ray crystallography, it is proposed that any of the feasible initial 1:1 nucleobase adducts of cisplatin could form dinuclear Pt complexes upon reaction with additional hydrolyzed cisplatin, thereby generating nucleobase adducts other than the presently established ones. Two findings appear to be of particular significance: First, hydrolyzed cisplatin can have a moderately accelerating effect on the formation of a secondary nucleobase product. Second, NH3ligands of the cisplatin moiety can be converted into bridging amido ligands following condensation with the diaqua species of cisplatin.
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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method