Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: catalyst-palladium. Introducing a new discovery about 52409-22-0, Name is Pd2(DBA)3
Room-Temperature and Transition-Metal-Free Intramolecular alpha-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles
A novel approach for the synthesis of tetracyclic indoles and 7-azaindoles is reported. The strategy involves four steps, with a fast rt intramolecular alpha-arylation of ketones as key step. The reaction was inspected synthetically to achieve the synthesis of 11 novel tetracyclic structures with moderate to very good yields (39-85%). Theoretical combined with experimental studies led us to propose a probable polar mechanism (concerted SNAr).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: catalyst-palladium, you can also check out more blogs about52409-22-0
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method