52522-40-4, Name is Tris(dibenzylideneacetone)dipalladium-chloroform, belongs to catalyst-palladium compound, is a common compound. HPLC of Formula: C52H43Cl3O3Pd2In an article, once mentioned the new application about 52522-40-4.
Highly Enantioselective Construction of Sterically Hindered alpha-Allyl-alpha-Aryl Lactones via Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation
Pd-catalyzed decarboxylative asymmetric allylic alkylation has been developed for sterically hindered alpha-aryl, beta-oxo-allyl ester lactone substrates. Pb-mediated alpha-arylation of the beta-oxo-allyl ester was used as the key step to synthesize the substrates for catalysis in moderate to high yields. Optimization studies for decarboxylative asymmetric allylic alkylations (DAAA) were conducted using delta-valerolactone-derived alpha-aryl beta-oxo-allyl ester with 2,4,6-trimethoxyphenyl as the aryl substituent. Using (R,R)-ANDEN-phenyl Trost as the chiral ligand, enantioselectivities of up to >99% ee and 98% ee were achieved with the six-membered and five-membered lactone substrates, respectively. Bulky aryl groups containing di-ortho substitutions and naphthyl groups gave the highest enantioselectivities. This synthetic route allows for the simple modification of aryl groups, giving highly enantioselective access to important structural motifs.
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Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method