One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II), such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 887919-35-9, Name is Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II), molecular formula is C32H56Cl2N2P2Pd
As part of an ongoing effort at Amgen to develop a disease-modifying therapy for Alzheimer’s disease, we have previously used the aminooxazoline xanthene (AOX) scaffold to generate potent and orally efficacious BACE1 inhibitors. While AOX-BACE1 inhibitors demonstrated acceptable cardiovascular safety margins, a retinal pathological finding in rat toxicological studies demanded further investigation. It has been widely postulated that such retinal toxicity might be related to off-target inhibition of Cathepsin D (CatD), a closely related aspartyl protease. We report the development of AOX-BACE1 inhibitors with improved selectivity against CatD by following a structure- and property-based approach. Our efforts culminated in the discovery of a picolinamide-substituted 3-aza-AOX-BACE1 inhibitor absent of retinal effects in an early screening rat toxicology study.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II), which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 887919-35-9
Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method