Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II). Introducing a new discovery about 887919-35-9, Name is Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)
A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladiumcatalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50%is a large improvement over the single, previous synthesis. By design, this modular route allows the rapid synthesis of other members of the protoberberine family (e.g., pseudocoptisine and palmatine) by substitution of the readily available aryl bromide and ketone coupling partners. Moreover, by combining enolate arylation with in situ functionalization, substituents can be rapidly and regioselectively introduced at the alkaloid C13 position, as demonstrated by the total synthesis of dehydrocorydaline. The avoidance of electrophilic aromatic substitution reactions to make the isoquinoline allows direct access to analogues possessing more varied electronic properties, such as the fluorine-containing derivative synthesized here.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II), you can also check out more blogs about887919-35-9
Reference：
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method