Formula: C10H8ClNO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-(2-Chlorophenyl)-5-isoxazolemethanol, is researched, Molecular C10H8ClNO2, CAS is 438565-33-4, about Efficient synthesis of bis-isoxazole ethers via 1,3-dipolar cycloaddition catalysed by Zn/Zn2+ and their antifungal activities. Author is Zhang, Da-Wei; Lin, Feng; Li, Bo-Chao; Liu, Hong-Wei; Zhao, Tian-Qi; Zhang, Yu-Min; Gu, Qiang.
A series of novel bis-isoxazole ether compounds I [R = 3-pyridyl, 3-O2NC6H4, 4-O2NC6H4, 4-(H3C)3CC6H4; R1 = 4-C(CH3)3, 3-NO2, (Z)-CH=CHC6H5, etc.] were synthesized starting from different substituted aldehydes RCHO and R1CHO via 1,3-dipolar cycloaddition using Zn/Zn2+ as a catalyst. In addition, the antimicrobial properties of synthesized products were investigated. The synthesized compounds I exhibited significant antifungal activities in comparison with the standard drugs, fluconazole and itraconazole. It was found that Candida albicans was sensitive to 2-substituted Ph bis-isoxazole ethers bearing pyridyl I [R1 = 2-OCH3, 2-Cl].
In addition to the literature in the link below, there is a lot of literature about this compound(3-(2-Chlorophenyl)-5-isoxazolemethanol)Formula: C10H8ClNO2, illustrating the importance and wide applicability of this compound(438565-33-4).
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method