The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Isoquinolin-6-ol, is researched, Molecular C9H7NO, CAS is 7651-82-3, about Photocatalytic N-heteroarylation of aldehydes via formyl C-H activation, the main research direction is photoredox catalyst heteroarylation aldehyde formyl carbon hydrogen activation; secondary alc aldehyde heteroarylation photoredox catalyst.Product Details of 7651-82-3.
A formyl C-H addition of N-heteroaromatics to aldehydes was achieved using a binary hybrid catalyst system comprising an acridinium photoredox catalyst and a thiophosphoric acid organocatalyst. The reaction proceeded through the following sequence: (1) photoredox-catalyzed single-electron oxidation of a thiophosphoric acid catalyst to generate a thiyl radical, (2) cleavage of the formyl C-H bond of the aldehyde substrates by a thiyl radical acting as a hydrogen atom transfer catalyst to generate acyl radicals, (3) Minisci-type addition of the resulting acyl radicals to N-heteroaromatics, and (4) a spin-center shift, photoredox-catalyzed single-electron reduction, and protonation to produce secondary alc. products. This metal-free hybrid catalysis proceeded under mild conditions for a wide range of substrates, including isoquinolines, quinolines, and pyridines as N-heteroaromatics, as well as both aromatic and aliphatic aldehydes, and tolerated various functional groups. The reaction was applicable to late-stage derivatization of drugs and their leads.
In addition to the literature in the link below, there is a lot of literature about this compound(Isoquinolin-6-ol)Product Details of 7651-82-3, illustrating the importance and wide applicability of this compound(7651-82-3).
Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method