Electric Literature of 52409-22-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 52409-22-0, Pd2(DBA)3, introducing its new discovery.
Improved synthesis of SV2A targeting radiotracer [11C]UCB-J
Introduction: [11C]UCB-J is a tracer developed for PET (positron emission tomography) that has high affinity towards synaptic vesicle glycoprotein 2A (SV2A), a protein believed to participate in the regulation of neurotransmitter release in neurons and endocrine cells. The localisation of SV2A in the synaptic terminals makes it a viable target for in vivo imaging of synaptic density in the brain. Several SV2A targeting compounds have been evaluated as PET tracers, including [11C]UCB-J, with the aim to facilitate studies of synaptic density in neurological diseases. The original two-step synthesis method failed in our hands to produce sufficient amounts of [11C]UCB-J, but served as an excellent starting point for further optimizations towards a high yielding and simplified one-step method. [11C]Methyl iodide was trapped in a clear THF-water solution containing the trifluoroborate substituted precursor, potassium carbonate and palladium complex. The resulting reaction mixture was heated at 70 C for 4 min to produce [11C]UCB-J. Results: After semi-preparative HPLC purification and reformulation in 10% ethanol/phosphate buffered saline, the product was obtained in 39 ¡À 5% radiochemical yield based on [11C]methyl iodide, corresponding to 1.8 ¡À 0.5 GBq at EOS. The radiochemical purity was > 99% and the molar activity was 390 ¡À 180 GBq/mumol at EOS. The product solution contained < 2 ppb palladium. Conclusions: A robust and high yielding production method has been developed for [11C]UCB-J, suitable for both preclinical and clinical PET applications. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 52409-22-0. In my other articles, you can also check out more blogs about 52409-22-0
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method