14871-92-2, Name is (2,2¡ä-Bipyridine)dichloropalladium(II), belongs to catalyst-palladium compound, is a common compound. Recommanded Product: 14871-92-2In an article, once mentioned the new application about 14871-92-2.
New palladium(II) and platinum(ii) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2?-bipyridine and 2,2?-dipyridylamine: Synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity
Novel palladium(ii) and platinum(ii) complexes of 5,5-diethylbarbiturate (barb) with 2-phenylpyridine (Hppy), 2,2?-bipyridine (bpy) and 2,2?-dipyridylamine (dpya) have been prepared and characterized by elemental analysis, IR, UV-Vis, NMR and ESI-MS. Single-crystal diffraction measurements show that complex 1 consists of binuclear [Pd2(mu-barb-kappaN,O)2(ppy-kappaN,C)2] moieties, while complexes 3-5 are mononuclear, [M(barb-kappaN)2(L-kappaN,N?)] (L = bpy or dpya). 6 has a composition of [Pt(dpya-kappaN,N?)2][Ag(barb-kappaN)2]2¡¤4H2O and 2 was assumed to have a structure of [Pt(barb-kappaN)(Hppy-kappaN)(ppy-kappaN,C)]¡¤3H2O. The complexes were found to exhibit significant DNA binding affinity by a non-covalent binding mode, in accordance with molecular docking studies. In addition, complexes 1 and 2 displayed strong binding with supercoiled pUC19 plasmid DNA. Cellular uptake studies were performed to assess the subcellular localization of the selected complexes. A moderate radical scavenging activity of 1 and 2 was confirmed by DPPH and ABTS tests. Complexes 1, 2, and 5 showed selectivity against HT-29 (colon) cell line.
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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method